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Treatment of Chemotherapy – Induced Peripheral Neuropathy: The Physicians Need Guidelines, the Patients Need Help- Pages 108-113

Krzysztof Brzeziński

Outpatient Pain Clinic, Institute of Rural Health, ul. Jaczewskiego 2, 20-090 Lublin, Poland



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    Abstract: The aim of the study was to verify the effectiveness of two methods of introducing standard CIPN-treatment drugs into the therapy.

    Materials and Methods: Group A included patients attending weekly appointments, while group B monthly. Standard treatment with amitriptyline, gabapentin (GAB), and oxycodone (OXY) was administered. In group A, the drugs were gradually introduced, while in group B – within one week. After a month and six months of treatment, the therapy effectiveness was assessed by examination of pain intensity (VAS), symptoms of peripheral neuropathy (sNCI-CTC), occurrence of tactile and brush allodynia, and the daily dose of GAB and OXY.

    Results: Pain intensity during the study decreased from 5.59 to 2.9 and 2.76 in group A, and from 5.07 to 2.52 and 2.81 in group B. The sNCI-CTC values declined too and were, respectively. 1.9; 1.48; 1.34 in group A and 1.93; 1.52; 1.44 in group B. Tactile allodynia occurred in 15; 5; 5 group A patients and 18; 6; 5 group B patients. Brush allodynia decreased in group A (9; 5; 5) and B (11; 6; 5). The daily GAB dose was 0; 951.72; 927.41 in group A and 900.0; 900.0; 1000.0 in group B. The daily OXY dose was 0; 21.72; 22.07 in group A and 20.0; 20.0; 27.04 in group B; a statistically significant difference was found in the final stage.

    The results do not allow recommendation of non-schematic treatment and they should be regarded as a preliminary study. Randomized trials are indispensable for assessment of advantages and drawbacks such treatment.

    Keywords: Chemotherapy induced peripheral neuropathy, neuropathy, neuropathic pain, cancer related pain, pain treatment, amitiptyline, gabapentin, oxycodone, treatment schedule, pain, tactile allodynia, brush allodynia.


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