Abdul Shukkur Ebrahim B.Sc., M.Sc., M.Phil., Ph.D.
Dept. of Internal Medicine-Hematology / Oncology
Wayne State University and School of Medicine,
Detroit, MI 48201,
B.Sc. in Biochemistry (University of Madras, Chennai, India)
M.Sc. in Biochemistry (University of Madras, Chennai, India)
M.Phil. in Biochemistry (University of Madras, Chennai, India)
Ph.D. in Biochemistry (University of Madras, Chennai, India)
Dr. Ebrahim, currently a Research Scientist at Wayne State University School of Medicine, has worked on the identification of novel biomarkers in Lymphoma stem cells, using a high-throughput proteomic approach 2-D Fluorescence Difference Gel Electrophoresis (2-D DIGE). His specific goal is to identify novel agents in the clinical level for developing novel therapeutic treatment strategies against lymphoma, especially CNS lymphoma (CNSL), Follicular Small Cleavage Cell Lymphoma (FSCCL), Waldenström’s Macroglobulinemia (WM) and Diffuse Large Cell Lymphoma (DLCL) using human samples, cell lines and xenograft mice models. Understanding the molecular pathways involved in the action of chemotherapeutic agents is important in designing new clinical protocols for use in the clinical setting. From 2007-2011 as a Research Associate at Mayo Clinic Jacksonville, he studied the pathological mechanisms of Alzheimer's disease, Parkinson’s disease and Corticobasal degeneration (CBD) with special emphasis on mitochondrial dysfunction and protein abnormalities in human brain tissues, rTg4510 mouse brain and alpha-Synuclein cell line models. Dr.Ebrahim continued to make contributions to the field, another noteworthy one being the identification of astrocyte associated LC ferritin as a biomarker for the neurodegenerative disease CBD using a high throughput 2D-DIGE technique. As a Research Scientist, at The RIKEN Brain Science Institute, Japan in the year 2002-2007, he studied the tau protein biochemistry, oxidative stress and mitochondrial dysfunctions in a mouse model of Down syndrome Ts1Cje and Ts2Cje. His work showed in an unbiased manner that Down’s syndrome and Alzheimer’s disease share common pathways of neurodegeneration and that modified brain proteins markers contribute to cognitive dysfunction and neurodegenerative processes occurring in DS. Dr. Ebrahim received an award MEXT Grants-in-Aid for scientific research (KAKENHI) from the Government of Japan. These grants are highly competitive in Japan and to have received a KAKENHI is a great honor! Dr. Ebrahim Abdul Shukkur was the recipient of Science and Technology Agency award (STA fellow award) from the Japan International Science and Technology Exchange Center (JISTEC) from 2000-2002. This again is a highly competitive national award that he received following studies on the cloning and characterization of a novel tumor suppressor gene (m-Kank) using a mouse genomic library.