Lifescience Global

Journal of Basic & Applied Sciences

Synthesis of Mannich Bases of 8-Hydroxyquinoline
Pages 539-543
Humaira Siddiqi, Shaheen Faizi, Shaista Naz and Erum Zahir

DOI: http://dx.doi.org/10.6000/1927-5129.2015.11.71

Published: 29 September 2015

Open Access

Abstract: In search of new potential therapeutic agents, 8-Hydroxyquinoline which is a highly active antifungal and antibacterial agent was subjected to Mannich reaction. Different combinations of aromatic aldehyde and aromatic amines were used for Mannich reaction on 8-Hydroxyquinoline from which one new 7-[α-(anilino)-3',4'-dimethoxybenzyl]-8-hydroxyquinoline (3) and two known Mannich bases (1,2) were obtained.

Keywords: 8-Hydroxyquinoline, Oxine, Mannich Base, Mannich Reaction.

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