Lifescience Global

jao

product-logo-jao 1340476205

Differences between 66 Chemical Element Contents in Normal and Cancerous Prostate
Pages 37-56
Vladimir Zaichick
DOI:
https://doi.org/10.6000/1927-7229.2017.06.02.1
Published: 25 April 2017


Abstract: Prostate cancer is an internationally important health problem in man, particularly in developed countries. The aim of this exploratory study was to clarify the differences between the prostatic levels of chemical elements in patients with malignantly transformed prostate (PCa) and healthy male inhabitance. Prostatic tissue levels of 66 chemical elements were prospectively evaluated in 60 patients with PCa and 37 healthy males. Measurements were performed using a combination of five non-destructive and destructive analytical methods. A significant increase in the mean level of Ag, Al, Au, B, Ba, Be, Bi, Br, Ce, Cr, Cu, Dy, Er, Fe, Gd, Hg, Ho, Li, Mn, Nd, Ni, Pr, Sb, Si, Sm, Sn, Sr, Tb, Th, Ti, Tl, Tm, Y and Zr accompanied a decrease in the mean level of Ca, Cd, Co, K, Mg, Na, P, Rb, S, Sc, Se, and Zn was observed in the cancerous prostates. It was not found any differences in the mean prostatic level of other chemical elements including Cs, La, Mo, Nb, P, Pb, U, and Yb between PCa patients and healthy males. This work’s results reveal that in malignantly transformed prostate the chemical element metabolism is drastically disturbed.

Keywords: Prostate cancer, prostatic chemical element contents, energy dispersive X-ray fluorescence analysis, neutron activation analysis, inductively coupled plasma atomic emission spectrometry, inductively coupled plasma mass spectrometry.

Download Full Article

 

Save

Save

product-logo-jao 1340476205

Prevalence of Precancerous Lesions among Positive HIV Women in the Hospital Complex and University of Yaounde (Cameroun)
Pages 103-106
Dominique Vanessa Sob Djuendje, Armel Herve Nwabo Kamdje and Blaise Nkegoum
DOI:
https://doi.org/10.6000/1927-7229.2017.06.02.3
Published: 25 April 2017


Abstract: In the year 2000, a wide campaign of screening and treatment of the dysplastic lesions of the cervix was initiated in Cameroun. The precancerous lesions of the cervix are the most important demonstration of gynecological infection by the AIDS. As these lesions remain little documented in Cameroun, we carried out a study which the goal was to determine the prevalence of the precancerous lesions among positive AIDS women.

It is about a descriptive study with a retrospective collection of data carried out between 2010 and 2016 among 253 positive AIDS women having carried out a consultation in the Hospital complex and University of Yaounde aged from 18 to 80 years. The analysis of the data was essentially carried on: the age, clinical Factors data of risk of the precancerous lesions, anatomo-pathological search of precancerous lesion. AIDS status and/or the catch the antiretroviral one. The Software SPSS was used for the analysis of data. The test of Chi2 for the comparison of the variables. A variable was considered significant if P<0,05.

53 women presented precancerous lesions i.e. 20,94%. The lesions were in 92% of the squamous lesions with intra epithelial of low rank and in 8% of the squamous lesions with intra epithelial of high rank. 22 women (38%) were aged between 36 and 45 years; 22 women (40%) were housewives; 18 women (31%) were single people; 36 women (67%) were multipares; 45 women (85%) did not smoke; 33 women (62%) had a peak of CD4 located between 500-1000/mm3;14 women (26%) did not have opportunist diseases 10 women (19%) had the zona, 8 women (15%) of tuberculosis and 9 women (17%) suffered from HTA.

Because of the high potential risk of precancerous lesions in our population of study, we recommend a regular clinical follow-up of the patients presenting high factors of risk, and a widened access to antiretroviral.

Keywords: Precancerous lesions, AIDS, Prevalence.

Download Full Article

 

Save

Save

product-logo-jao 1340476205

Prevalence of Malnutrition among Cancer Patients in a Nigerian Institution
Pages 117-124
Atara Isaiah Ntekim, Oluyemisi Folake Folasire and Ayorinde Mobolande Folasire
DOI:
https://doi.org/10.6000/1927-7229.2017.06.02.5
Published: 25 April 2017


Abstract: Background: Cancer is a major health problem. Successful management includes adequate supportive care. Nutritional problems are common among cancer patients and these are not routinely addressed by oncologists during oncology care leading to suboptimal outcome even in developed countries. In Nigeria and other low and medium income countries, the situation is worse as nutritional screening and assessment of cancer patients are not routinely carried out.

Objectives: To determine the proportion of cancer patients at risk of malnutrition and compare convergence of risk assessment using SGA and MUST tools.

Methods: This was a prospective study carried out among cancer patients who presented for cancer care in the Department of Radiation Oncology, University College Hospital Ibadan, Nigeria. Nutritional assessment tools which included Malnutrition Universal Scoring Tool (MUST) and Subjective Global Assessment (SGA) were used to assess the nutritional status of the participants.

Results: A total of 89 patients aged between 18 and 85 years participated in the study. The number of males were 13 (15%) while females were 76(85%). In our study 54 (60.8%) of our patients were at risk of malnutrition using the malnutrition universal scoring tool (MUST) scale while 53(60%) were malnourished using the subjective global assessment (SGA) scale. The reliability for the classifications using the MUST and SGA scales was positive (moderate) [Kappa = 0.584 (p<0.0005), 95% CI (0.410, 0.758)].

Conclusion: There is a high proportion of clinical malnutrition among cancer patients in the study population. According to this study, there was similarity between the classifications of nutritional risk, using the MUST and SGA tools.

Keywords: Nutrition, Status, oncology, MUST, SGA, nutritional assessment.

Download Full Article

 

Save

Save

product-logo-jao 1340476205

In silico Meta-Analysis of Circulatory microRNAs in Prostate Cancer

Anshika N. Singh and Neeti Sharma
DOI:
https://doi.org/10.6000/1927-7229.2017.06.02.4
Published: 25 April 2017


Abstract: Circulatory microRNAs (miRNAs) have emerged as a new class of non coding RNA molecules which regulate many crucial molecular and biological processes. We have aimed to shed light on the roles of circulatory miRNAs in Prostate Cancer (PCa) using an integrative in silico bioinformatics approach. We have described a new protocol for target prediction and functional analysis which was applied to 40 highly differentially dysregulatedcirculatory miRNAs in PCa. This framework comprises: (i) evidence of involvement of these circulatory miRNAs from previous literature and microarray analysis (ii) overlap of prediction results by target prediction tools, including miRTarBase, miRDB, DIANA- microT 4.0 and TargetScan (combining computational learning, alignment, interaction energy and statistical tests for minimization of false positives), (iii) gene ontology (GO) along with pathway enrichment analysis of the miRNA targets and their pathways and (iv) linking these pathways to oncogenesis and cancer hallmarks. More than 200 target genes and 40 regulatory pathways were retrieved and analysed which was followed by associating their roles with cancer hallmark processes. Wnt signalling, Cell cycle, MAPK signalling, Cadherin signalling, Integrin signalling and Ras pathways were some of the identified regulatory pathways during bioinformatics analysis. These signalling and developmental pathways crosstalk and regulate stem cell renewal thus indicating a definite role of circulatory miRNAs in PCa development. Our study identified miR-181, miR-9, Let-7 family, miR-26b circulatory miRNAs, to be contributing majorly in the oncogenic pathways, thus proposing their role as potential biomarkers in PCa initiation and progression.

Keywords: Prostate Cancer, microRNA, Target prediction, Cancer hallmarks.

Download Full Article

 

Save

Save

product-logo-jao 1340476205

Breast Cancer Treatment Protocols: Systematic Review of the Last 35 Years
Pages 57-102
Thais Ligiero Braga, Filipe Leal Portilho and Ralph Santos-Oliveira
DOI:
https://doi.org/10.6000/1927-7229.2017.06.02.2
Published: 25 April 2017


Abstract: Breast cancer is the main leading type of cancer for women around the world and is responsible for 522,000 deaths per year worldwide. In order to reduce this number, clinicians and researchers are always looking for new strategies and protocols. However, the treatment for breast cancer is challenging and requires as much information as possible. To this end, we conducted a review of all protocols used for breast cancer treatment in the last 35 years with the objective to help clinicians to choose the best treatment possible available in their region. Many of the protocols are international references, and for that reason have been used in many countries like USA and Europe. The data, depicted in tables, may be helpful for clinicians worldwide and researchers to better understand the evolution of breast cancer protocols such as helping make daily routine decisions.

Keywords: Breast cancer, protocols, systematic review.

Download Full Article

 

Save

Save

OUR STRENGTHS

♦  Worldwide readership
♦  High quality content
♦  Maximum visibility
♦  Efficient publishing
♦  Optional Open Access

Publish your Research

Survey

As an author what type of publishing model you prefer?

780
Open Access
493
Optional Open Access
338
Subscription based
5 Votes left