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Editor’s Choice : Molecular Genetic Study of the Allelic State of the Cell Cycle Genes (TP53, BRCA1) and Features of the Regulation of the Cytokine Cascade in Breast Cancer

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Molecular Genetic Study of the Allelic State of the Cell Cycle Genes (TP53, BRCA1) and Features of the Regulation of the Cytokine Cascade in Breast Cancer
Pages 211-219
S.K. Gantsev, V.Y. Gorbunova, G.F. Galikeeva, E.V. Vorobyeva, E.M. Vasilyeva and R.A. Rustamhanov

DOI: http://dx.doi.org/10.6000/1929-2279.2013.02.03.6

Published: 1 July 2013 


Abstract: This article contains the analysis of mutations in genes that regulate the cell cycle (TP53 and BRCA1) and classification relating to tumor suppressor. Shown that the "risk" alleles of these genes may contribute to tumor development, but the activation of the immune system cytokine spectrum of patients can prevent their destructive degeneration. The authors proposed a personalized approach to the study for the prevention of possible proliferative processes. This is confirmed by reversal of "risk" alleles studied genes in tumors in operated patients with cytokine physiologically normal status.

Keywords: Breast cancer, tumor suppressor, cytokines, nucleotide substitutions, predisposition.
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