Lifescience Global

Journal of Membrane and Separation Technology

Preparation and Characterization of Cellulose Membrane Modified with β-Cyclodextrin for Chiral Separation
Pages 88-94
Yibing Ji, Jian Ke, Feifei Duan and Jianqiu Chen

DOI: http://dx.doi.org/10.6000/1929-6037.2016.05.03.1

Published: 26 October 2016

 


Abstract: In this study, it is first time to obtain a complete separation of using β-cyclodextrin (β-CD) modified cellulose microfiltration membrane. Commercially cellulose membrane with the pore diameter of 0.22μm was functionalized with β-cyclodextrin (β-CD) by aldolization at the solid–liquid interface. Filtration experiments were carried out using a dead-end filtration cell holding a flat sheet membrane with effective area of 36 mm2. Aqueous solution of racemic tryptophan (0.05g/L, 150 mL) was forced to permeate through the cellulose membrane immobilized by β-CD at a flow rate of 0.1 ml/min through the membrane microdevice. Chiral ligand exchange chromatography was used to determine the concentration and ratio of D- and L-tryptophan in the filtrate. A complete separation of racemic tryptophan can be obtained by using this novel composite membrane-based separation system. In addition, a multi-stage filtration separation was applied in order to obtain higher permselectivity. The objective of this study is to obtain an easy prepared chiral membrane with good reproducibility and can be applied to a variety of chiral separations.

Keywords: Cellulose membrane, Enantiomeric separation, Glutaraldehyde, Tryptophan, Multi-stage filtration.
Download Full Article
Submit to FacebookSubmit to Google PlusSubmit to TwitterSubmit to LinkedIn

OUR STRENGTHS

♦  Worldwide readership
♦  High quality content
♦  Maximum visibility
♦  Efficient publishing
♦  Optional Open Access

Publish your Research

Survey

As an author what type of publishing model you prefer?

780
Open Access
493
Optional Open Access
338
Subscription based
5 Votes left