Study of Multi-Drug Resistance Associated with Anti-Tuberculosis Treatment by DOT Implementation Strategy in Pakistan

Sana Saeed, Moosa Raza, Maryam Shabbir, Muhammad Furqan Akhtar, Ali Sharif, Muhammad Zaman, Sajid Ali, Sajid Nawaz, Ayesha Saeed


Purpose: The present prospective cross sectional study was aimed to access the prevalence and trend of Multi-Drug Resistant Tuberculosis (MDR-TB) in different age groups and gender, in the city of Lahore, Pakistan. Tuberculosis is a disease of poverty affecting mostly young adults in their most productive years; however, all age groups are at risk.

Method: The study population consisted of patients under DOT program with MDR-TB among males and females and in different categories of age groups. The data was collected from 100 MDR-TB patients from 7800 TB patients that were admitted in duration of 6 months and analyzed to evaluate the drug resistance associated with patient’s noncompliance. Moreover, drugs resistance ratio was also calculated from the data.

Results: TB is a specific infectious disease, caused by M. tuberculosis strains, which is becoming resistant to anti-tuberculosis agents especially to Isoniazid and Rifampicin that are two key drugs of TB treatment and are termed as MDR-TB. The disease was seen in 66% males and 34% in female. The highest drug resistance ratio was in found in adults (age group).


Multi Drug Resistance, Tuberculosis, DOT, Lahore, M. tuberculosis.

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ISSN: 1927-5129