Amidoalkyl Naphthols: Trifluoroacetic Acid (TFA) Catalyzed One-Pot, Multi-Component Synthesis

Authors

  • Vinay S. Kadam The Maharaja Sayajirao University of Baroda
  • Priyanka R. Khanvilkar The Maharaja Sayajirao University of Baroda
  • Arun L. Patel The Maharaja Sayajirao University of Baroda

DOI:

https://doi.org/10.6000/1929-5030.2013.02.04.8

Keywords:

Amidoalkyl naphthols, multicomponent reaction, solvent-free conditions, trifluoroacetic acid

Abstract

Trifluoroacetic acid (TFA) was found as an efficient catalyst for the synthesis of amidoalkyl naphthols from aromatic aldehydes, β-naphthol and acetamide/benzamide under solvent free condition at 80o C. All the synthesized compounds were characterized by IR, 1H NMR and Mass spectra. The advantages of the new method were good yields, short reaction times, simple work-up, inexpensive and easily available catalyst and economical due to absence of solvent. Therefore, this method could be an attractive alternative to existing methods for the synthesis of biologically important amidoalkyl naphthols.

Author Biographies

Vinay S. Kadam, The Maharaja Sayajirao University of Baroda

Department of Chemistry, Faculty of Science

Priyanka R. Khanvilkar, The Maharaja Sayajirao University of Baroda

Department of Chemistry, Faculty of Science

Arun L. Patel, The Maharaja Sayajirao University of Baroda

Department of Chemistry, Faculty of Science

References


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Published

2013-11-25

How to Cite

Kadam, V. S., Khanvilkar, P. R., & Patel, A. L. (2013). Amidoalkyl Naphthols: Trifluoroacetic Acid (TFA) Catalyzed One-Pot, Multi-Component Synthesis. Journal of Applied Solution Chemistry and Modeling, 2(4), 263–268. https://doi.org/10.6000/1929-5030.2013.02.04.8

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General Articles