Solubilization of Hydroxypropyl-β-Cyclodextrin on Cholesterol in Aqueous Solution
DOI:
https://doi.org/10.6000/1929-5030.2014.03.02.1Keywords:
Cholesterol, Solubilization, Optimal condition, Inclusion, Hydroxypropyl-beta-CyclodextrinAbstract
Hydroxypropyl-β-Cyclodextrin (HP-β-CD), prepared via reaction of β-Cyclodextrin (β-CD) and propylene oxide (PO), is utilized to research solubilization of HP-β-CD on cholesterol in aqueous solution. HP-β-CD is characterized by Fourier Transform Infrared Spectrometry (FT-IR), and concentrations of cholesterol solution are measured by ultraviolet and visible (UV VIS) spectrophotometer. The research on optimal synthesis conditions of HP-β-CD indicates that sodium hydroxide amounts have the most effect on yields of product. The maximum solubilization multiples of HP-β-CD reaches 15, below which molecular rate of HP-β-CD and cholesterol in inclusion complex is 1:1.
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Published
2014-05-02
How to Cite
Zou, C., Zhou, L., Wang, Y., & Li, L. (2014). Solubilization of Hydroxypropyl-β-Cyclodextrin on Cholesterol in Aqueous Solution. Journal of Applied Solution Chemistry and Modeling, 3(2), 48–52. https://doi.org/10.6000/1929-5030.2014.03.02.1
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