Preferential Solvation of Acetaminophen in Propylene Glycol + Water Co-Solvent Mixtures
DOI:
https://doi.org/10.6000/1929-5030.2014.03.02.4Keywords:
Acetaminophen, propylene glycol, solubility, inverse Kirkwood-Buff integrals, preferential solvation.Abstract
The preferential solvation parameters defined as the differences between the local mole fraction of solvents around analgesic drug acetaminophen and those for the bulk co-solvent composition in propylene glycol + water mixtures were derived from their thermodynamic properties by means of the inverse Kirkwood-Buff integrals (IKBI) and the quasi-lattice-quasi-chemical (QLQC) methods. It is found that acetaminophen is sensitive to solvation effects, so according to IKBI method the preferential solvation parameter δ´xPG,A, is negative in water-rich mixtures but positive in medium compositions and in co-solvent-rich mixtures. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic ring and methyl group present in the drug plays a relevant role in the solvation. The bigger drug solvation by co-solvent in mixtures of similar solvent proportions and in propylene glycol-rich mixtures could be due mainly to polarity effects. Otherwise, according to QLQC method, this drug is preferentially solvated by the co-solvent in all the mixtures.
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Published
2014-06-02
How to Cite
Peña, M. Ángeles ., Delgado, D. R., & Martínez, F. (2014). Preferential Solvation of Acetaminophen in Propylene Glycol + Water Co-Solvent Mixtures. Journal of Applied Solution Chemistry and Modeling, 3(2), 65–73. https://doi.org/10.6000/1929-5030.2014.03.02.4
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