Antioxidant Compounds of the Edible Mushroom Pleurotus ostreatus

Authors

  • Hesham Ali El- Enshasy Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt
  • Shanmugaprakasham Selvamani Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM),
  • Daniel Joe Dailin Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM),
  • Roslinda Abd Malek Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru
  • Siti Zulaiha Hanapi Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru
  • Kugan Kumar Ambehabati Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM),
  • Dalia Sukmawati Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Kampus B, Pemuda Street No. 10 Rawamangun,
  • Ong Mei Leng Harita Go Green Sdn. Bhd., Johor Bahru, Johor
  • Neo Moloi Sawubona Mycelium Co., Centurion, Gauteng

DOI:

https://doi.org/10.6000/1927-3037.2018.07.01

Keywords:

Pleurotus ostreatus, antioxidants, fruiting bodies, mycelium, mushroom bioactives.

Abstract

Mushrooms have been used since centuries in many ancient cultures as source of food and medicine. However, until now the therapeutic values of mushrooms position this group of macrofungi as one of the major component in traditional medicine practice especially in South East Asia and China. Of different species of known mushrooms, Pleurotus spp. is widely known as part of food chain based on its high nutritional value. However, of the more than 70 species known, only few species are cultivated in mass production and used such as P. ostreatus, P. florida, and P. ajor-caju. However, P. ostreatus (widely known as oyster mushroom) received more attention in food industries based on its high growth rate and ease of cultivation using different substrates. This mushroom is rich of wide range of bioactive molecules of proven medicinal values with many therapeutic activities as anticancer, immunomodulatory, antiapoptotic, anti hypocholesterolemic, anti hyperglycemic, antimicrobial, anti-inflammatory, anti-osteoporetic, and many others. This work focuses on reviewing on the different classes of oyster mushroom bioactive compounds of antioxidant activities such as phenolics, beta carotene, lycopene, ascorbic acid, tocopherols, and ergosterols. This review provides also comprehensive information on the recent research to enhance the antioxidant properties through alteration of the cultivation strategy and addition of some compounds during the cultivation of P. ostreatus.

References

Sarangarajan R, Meera S, Rukkumani R, et al. Antioxidants: friend or foe? Asian Pac J Trop Dis 2017; 10 (12): 1111-6. http://dx.doi.org/10.1016/j.apjtm.2017.10.017

Thorat ID, Jagtap DD, Mohapatra D, et al. Antioxidants, their properties, uses in food products and their legal implications. Int J Food Studies 2013; 2: 1. [cited 2018 June 8]: Available from: https://www.iseki-food-ejournal.com/ojs/index.php/ejournal/ article/view/ 134.

Thyagarajan-Sahu A, Sahu RP. Potential contributions of antioxidants to cancer therapy: immunomodulation and radiosensitization. Integr Cancer Sci Ther 2017; 17(2): 210-6. http://dx.doi.org/10.1177/1534735416681639

González-Rodríguez ML, Fernández-Romero AM, Rabasco AM. Towards the antioxidant therapy in osteoarthritis: contribution of nanotechnology. J Drug Deliv Sci Technol 2017; 42: 94-106. http://dx.doi.org/10.1016/j.jddst.2017.04.032

Mao XY, Jin MZ, Chen JF, et al. Live or let die: neuroprotective and anti-cancer effects of nutraceutical antioxidants. Pharmacol Ther 2017; 183(1): 137-51. http://dx.doi.org/10.1016/j.pharmthera.2017.10.012

Ighodaro OM, Akinloye OA. First line defence antioxidantssuperoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Bull Alexandria Fac 2017: In press. http://dx.doi.org/10.1016/j.ajme.2017.09.001

Miro?czuk-Chodakowska I, Witkowska AM, Zujko ME. Endogenous non-enzymatic antioxidants in the human body. Adv Med Sci 2018; 63(1): 68-78. http://dx.doi.org/10.1016/j.advms.2017.05.005

Abdel-Hameed ES, Nagaty MA, Salman MS, et al. Phytochemicals, nutritionals and antioxidant properties of two prickly pear cactus cultivars (Opuntia ficus indica Mill.) growing in Taif, KSA. Food Chem 2014; 160: 31-8. http://dx.doi.org/10.1016/j.foodchem.2014.03.060

Xu X, Guo S, Hao X, et al. Improving antioxidant and antiproliferative activities of colla corii asini hydrolysates using ginkgo biloba extracts. Food Sci Nutr 2018; 6(4): 765-72. http://dx.doi.org/10.1002/fsn3.587

Si W, Chen YP, Zhang J, et al. Antioxidant activities of ginger extract and its constituents toward lipids. Food Chem 2018; 239: 1117-25. http://dx.doi.org/10.1016/j.foodchem.2017.07.055

El-Enshasy HA, Hatti-Kaul R. Mushroom immunomodulators: unique molecules with unlimited applications. Trends Biotechnol 2013; 31(12): 668-77. http://dx.doi.org/10.1016/j.tibtech.2013.09.003

Donlao N, Ogawa Y. Impacts of processing conditions on digestive recovery of polyphenolic compounds and stability of the antioxidant activity of green tea infusion during in vitro gastrointestinal digestion. LWT - Food Sci Technol 2018; 89: 648-56. http://dx.doi.org/10.1016/j.lwt.2017.11.051

Castro ACCM, Oda FB, Almeida-Cincotto MGJ, et al. Green coffee seed residue: A sustainable source of antioxidant compounds. Food Chem 2018; 246: 48-57. http://dx.doi.org/10.1016/j.foodchem.2017.10.153

Kalaras MD, Richie JP, Calcagnotto A, et al. Mushrooms: a rich source of the antioxidants ergothioneine and glutathione. Food Chem 2017; 233: 429-33. http://dx.doi.org/10.1016/j.foodchem.2017.04.109

Soltani M, Kamyab H, El Enshasy HA. Molecular weight (MW) and monosaccharide composition (MC): Two major factors affecting the therapeutic action of polysaccharides extracted from Cordyceps sinensisi. J Pure Appl Microbiol 2013; 7(3): 1601-13. [cited 2018 June 8]: Available from: http://www.microbiologyjournal.org/archive_mg/jmabsread.ph p

Elsayed EA, El Enshasy HA, Al Wadaan MA, et al. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm 2014; 805841. http://dx.doi.org/10.1155/2014/805841

El Enshasy HA, Daba, El Demellawy M, et al. Bioprocess development for large scale production of anticancer exopolysaccharide by Pleurotus ostreatus in submerged culture. J Appl Sci 2010; 10: 2523-9. http://dx.doi.org/10.3923/jas.2010.2523.2529

Maftoun P, Malek R, Abbas M, et al. Bioprocess for semiindustrial production of immunomodulator polysaccharide Pleuran by Pleurotus ostreatus in submerged culture. J Sci Ind Res 2013; 72: 655-62. http://dx.doi.org/10.3923/jas.2010.2523.2529

Maftoun P, Johari H, Soltani M, et al. (2015). The edible mushroom Pleurotus spp: I. Biodiversity and nutritional values. Int J Biotechnol Wellness Ind 2015; 4: 67-83. http://dx.doi.org/10.6000/1927-3037.2015.04.02.4

Mohamed EM, Farghaly FA. Bioactive compounds of fresh and dried Pleurotus ostreatus mushroom. Int J Biotechnol Wellness Ind 2014; 3: 15-8. http://dx.doi.org/10.6000/1927-3037.2014.03.01.2

Masri HJMHJ, Maftoun PMP, Malek RA, et al. The edible mushroom pleurotus spp.: ii. medicinal values. Int J Biotechnol Wellness Ind 2017; 6(1): 1-11. http://dx.doi.org/10.6000/1927-3037.2017.06.01.1

Jayakumar T, Thomas P, Sheu J, et al. In-vitro and in-vivo antioxidant effects of the oyster mushroom Pleurotus ostreatus. Food Res Int 2011; 44(4): 851-61. http://dx.doi.org/10.1016/j.foodres.2011.03.015

Heleno SA, Martins A, Queiroz MJ, et al. Bioactivity of phenolic acids: Metabolites versus parent compounds: A review. Food Chem 2015; 73: 501-13. http://dx.doi.org/10.1016/j.foodchem.2014.10.057

Sanchez C. Reactive oxygen species and antioxidant properties from mushrooms. Synth Syst Biotechnol 2017; 2: 13-22. http://dx.doi.org/10.1016/j.synbio.2016.12.001

Palacios I, Lozano M, Moro C, et al. Antioxidant properties of phenolic compounds occurring in edible mushrooms. Food Chem 2011; 128(3): 674-8. http://dx.doi.org/10.1016/j.foodchem.2011.03.085

G?secka M, Mleczek M, Siwulski M, et al. The effect of selenium on phenolics and flavonoids in selected edible white rot fungi. LWT - Food Sci Technol 2015; 63(1): 726-31. http://dx.doi.org/10.1016/j.lwt.2015.03.046

Arbaayah HH, Umi KY. Antioxidant properties in the oyster mushrooms (Pleurotus spp.) and split gill mushroom (Schizophyllum commune) ethanolic extracts. Mycosphere 2013; 4: 661-73. http://dx.doi.org/10.5943/mycosphere/4/4/2

G?secka M, Mleczek M, Siwulski M, et al. Phenolic composition and antioxidant properties of Pleurotus ostreatus and Pleurotus eryngii enriched with selenium and zinc. Eur Food Res Technol 2016; 242(5): 723-32. http://dx.doi.org/10.1007/s00217-015-2580-1

Woldegiorgis AZ, Abate D, Haki, GD, et al. Antioxidant property of edible mushrooms collected from Ethiopia. Food Chem 2014; 157(15): 30-6. http://dx.doi.org/10.1016/j.foodchem.2014.02.014

Reis FS, Martins A, Barros L, et al. Antioxidant properties and phenolic profile of the most widely appreciated cultivated mushrooms: A comparative study between in vivo and in vitro samples. Food Chem Toxicol 2012; 50(5): 1201-7. http://dx.doi.org/10.1016/j.fct.2012.02.013

Kim M, Seguin P, Ahn J, et al. Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. J Agric Food Chem 2008; 56(16): 7265-70. http://dx.doi.org/10.1021/jf8008553

Dong J, Zhang M, Lu L, et al. Nitric oxide fumigation stimulates flavonoid and phenolic accumulation and enhances antioxidant activity of mushroom. Food Chem 2012; 135(3): 1220-5. http://dx.doi.org/10.1016/j.foodchem.2012.05.055

Jiang T, Zheng X, Li J, et al. Integrated application of nitric oxide and modified atmosphere packaging to improve quality retention of button mushroom (Agaricus bisporus). Food Chem 2011; 126(4): 1693-9. http://dx.doi.org/10.1016/j.foodchem.2010.12.060

Anantharaju PG, Gowda PC, Vimalambike MG, et al. An overview on the role of dietary phenolics for the treatment of cancers. Nut J 2016; 15: 99. http://dx.doi.org/10.1186/s12937-016-0217-2

Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci. World J 2013: 162750. http://dx.doi.org/10.1155/2013/162750

Jeena GS, Punetha H, Prakash O, et al. Study on in vitro antioxidant potential of some cultivated Pleurotus species (Oyster mushroom). Indian J Nat Prod Resour 2014; 5(1): 56-61. [cited 2018 June 8]: Available from http://14.139.47.23/index.php/IJNPR/article/view/12457

González-Palma I, Escalona-Buendía HB, Ponce-Alquicira E, et al. Evaluation of the antioxidant activity of aqueous and methanol extracts of Pleurotus ostreatus in different growth stages. Front Microbiol 2016; 7: 1099. http://dx.doi.org/10.3389/fmicb.2016.01099

Gil-Ramírez A, Pavo-Caballero C, Baeza E, et al. Mushrooms do not contain flavonoids. J Funct Foods 2016; 25: 1-13. http://dx.doi.org/10.1016/j.jff.2016.05.005

Barros L, Dueñas M, Ferreira IC, et al. Phenolic acids determination by HPLC–DAD–ESI/MS in sixteen different Portuguese wild mushrooms species. Food Chem Toxicol 2009; 47(6): 1076-9. http://dx.doi.org/10.1016/j.fct.2009.01.039

Kang H, Kim H. Astaxanthin and ?-carotene in Helicobacter pylori-induced gastric inflammation: a mini-review on action mechanisms. J Cancer Prev 2017; 22(2): 57-61. http://dx.doi.org/10.15430/JCP.2017.22.2.57

Vrolijk M, Opperhuzen A, Jansen E, et al. The shifting perception on antioxidants: the case of vitamin E and ?carotene. Redox Biol 2015; 4: 272-8. http://dx.doi.org/10.1016/j.redox.2014.12.017

Krinsky N. Carotenoids as antioxidants. Nutr 2001; 17(10): 815-7. http://dx.doi.org/10.1016/S0899-9007(01)00651-7

Jayakumar T, Thomas P, Geraldine P. In-vitro antioxidant activities of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus. Innov Food Sci Emerg Technol 2009; 10(2): 228-34. http://dx.doi.org/10.1016/j.ifset.2008.07.002

Robaszkiewicz A, Bartosz G, ?awrynowicz M, et al. The role of polyphenols, ?-carotene, and lycopene in the antioxidative action of the extracts of dried, edible mushrooms. J Nutr Metab 2010: 173274. http://dx.doi.org/10.1155/2010/173274

Jaworska G, Pogo? K, Berna? E, et al. Nutraceuticals and antioxidant activity of prepared for consumption commercial mushrooms Agaricus bisporus and Pleurotus ostreatus. J Food Quality 2015; 38(2): 111-22. http://dx.doi.org/10.1111/jfq.12132

Mishra KK, Pal RS, Arunkumar R. Antioxidant activities and bioactive compound determination from caps and stipes of specialty medicinal mushrooms Calocybe indica and Pleurotus sajor-caju (higher basidiomycetes) from India. Int J Med Mushrooms 2014; 16(6): 555-67. http://dx.doi.org/10.1615/intjmedmushrooms.v16.i6.50

Carocho M, Barreiro MF, Morales P, et al. Adding molecules to food, pros and cons: a review on synthetic and natural food additives. Compr Rev Food Sci Food Saf 2014; 13(4): 377-99. http://dx.doi.org/10.1111/1541-4337.12065

Sies H, Stahl W. Vitamins E and C, a-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 2018; 62(6): 1315S-21. http://dx.doi.org/10.1093/ajcn/62.6.1315S

Yang JH, Lin HC, Mau J. Antioxidant properties of several commercial mushrooms. Food Chem 2002; 77: 229-35. http://dx.doi.org/10.1016/S0308-8146(01)00342-9

Sorice A, Guerriero E, Capone F, et al. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini Rev Med Chem 2014; 14(5): 444-52. http://dx.doi.org/10.2174/1389557514666140428112602

Mattila PH, Karoliina KN, Merja E, et al. Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. J Agric Food Chem 2001; 49; 2343- 48. http://dx.doi.org/10.1021/jf001525d

Jonathan SG, Okon CB, Oyelakin AO, et al. Nutritional values of oyster mushroom (Pleurotus ostreatus) (Jacq.Fr.) Kumm. cultivated on different agricultural wastes. Nat Sci 2012; 10(9): 186–91. [cited 2018 June 8]: Available from http://free-journal.umm.ac.id/detail-7107-title-nutritionalvalues-of-oyster-mushroom-pleurotus-ostreatus-jacq-frkumm-cultivated-on-different-agricultural-wastes.html

Brewer M. Natural antioxidants: sources, compounds, mechanisms of action and potential application. Compr Rev Food Sci Food Saf 2011; 10: 221-47. http://dx.doi.org/10.1111/j.1541-4337.2011.00156.x

Ferreira I, Barros L, Abreu R. Antioxidants in wild mushrooms. Curr Med Chem 2009; 16(12): 1543-60. http://dx.doi.org/10.2174/092986709787909587

Fernandes A, Barros L, Martins A, et al. Nutritional characterisation of Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm. produced using paper scraps as substrate. Food Chem 2015; 169: 396-400. http://dx.doi.org/10.1016/j.foodchem.2014.08.027

Karacsonyi S, Kuniak K. Polysaccharides of Pleurotus ostreatus: isolation and structure of pleuran, an alkaliinsoluble ?-D-glucan. Carbohydr Polym 1994; 24(2): 107-11. http://dx.doi.org/10.1016/0144-8617(94)90019-1

Wang JC, Hu HS, Liang ZC. Optimization for the production of water-soluble polysaccharide from Pleurotus citrinopileatus in submerged culture and its antitumor effect. Appl Microbiol Biotechnol 2005; 67(6); 759-66. http://dx.doi.org/10.1007/s00253-004-1833-x

Bae J, Sinha J, Park J, et al. Optimization of submerged culture conditions for exo-biopolymer production by Paecilomyces japonica. J Microbiol Biotechnol 2000; 10: 482-7. http://dx.doi.org/10.1111/j.1472-765x.2006.01884.x

Elisashvili VI, Kachlishvili ET, Wasser SP. Carbon and nitrogen source effects on basidiomycetes exopolysaccharide production. Appl Biochem Microbiol 2009; 45(5): 531-5. http://dx.doi.org/10.1134/s0003683809050135

Bobek P, Nosalova V, Cerna S. Effect of pleuran (betaglucan Pleurotus ostreatus) in diet or drinking fluid on colitis rats. Food Nahrung 2001; 45(5): 360. http://dx.doi.org/10.1002/1521-3803(20011001)45:53.0.co; 2-c

Rop O, Micek J, Jurikova T. Beta-glucans in higher fungi nd their health effects. Nutr Rev 2009; 67: 624-31. http://dx.doi.org/10.1111/j.1753-4887.2009.00230.x

Sun Y, Liu J. Purification, structure and immunobiological activity of a water-soluble polysaccharide from the fruiting body of Pleurotus ostreatus. Bioresour Technol 2009; 100(2): 983-6. http://dx.doi.org/10.1016/j.biortech.2008.06.036

El-Enshasy HA, Maftoun P, Abd-Malek R. Pleuran: Immunomodulators polysaccharide from Pleurotus ostreatus, structure, production and applications. In; Andres S, Baumann N, editors. Mushrooms; Types, properties, and nutrition. Malaysia: Nova Science Publishers 2012.

Jesenak M, Majtan J, Rennerova Z, et al. Immunomodulatory effect of pleuran (?-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Int Immunopharmacol 2013; 15(2): 395-9. http://dx.doi.org/10.1016/j.intimp.2012.11.020

Chen S, Huang S, Cheng M, et al. Enhancement of vitamin D2 content in Pleurotus mushrooms using pulsed light. J Food Process Preserv 2015; 39: 2027-34. http://dx.doi.org/10.1111/jfpp.12443

Barreira JC, Oliveira MB, Ferreira IC. Development of a novel methodology for the analysis of ergosterol in mushrooms. Food Anal Methods 2013; 7(1): 217-23. http://dx.doi.org/10.1007/s12161-013-9621-9

Krings U, Berger RG. Dynamics of sterols and fatty acids during UV-B treatment of oyster mushroom. Food Chem 2014; 149: 10-4. http://dx.doi.org/10.1016/j.foodchem.2013.10.064

Taofiq O, Heleno S, Calhelha R, et al. Development of mushroom-based cosmeceutical formulations with antiinflammatory, anti-tyrosinase, antioxidant, and antibacterial properties. Molecules 2016; 21(10): 1372. http://dx.doi.org/10.3390/molecules21101372

Vieira FPA, Gontijo DC, Vieira BC, et al. Antioxidant activities, total phenolics and metal contents in Pleurotus ostreatus mushrooms enriched with iron, zinc or lithium. LWT - Food Sci Technol 2013; 54(2): 421-5. http://dx.doi.org/10.1016/j.lwt.2013.06.016

Pisoschi A, Pop A. The role of antioxidants in the chemistry of oxidative stress: a review. Eur J Pharm Sci 2015; 97: 55- 74. http://dx.doi.org/10.1016/j.ejmech.2015.04.040

Li H, Zhang Z, Li M, et al. Yield, size, nutritional value, and antioxidant activity of oyster mushrooms grown on Perilla stalks. Saudi J Biol Sci 2017; 24(2): 347-54. http://dx.doi.org/10.1016/j.sjbs.2015.10.001

Choi Y, Lee SM, Chun J, et al. Influence of heat treatment on the antioxidant activities and polyphenolic compounds of Shiitake (Lentinusedodes) mushroom. Food Chem 2006; 99: 381-7. http://dx.doi.org/10.1016/j.foodchem.2005.08.004

Radzki W, Ziaja-So?tys M, Nowak J, et al. Effect of processing on the content and biological activity of polysaccharides from Pleurotus ostreatus mushroom. LWT - Food Sci Technol 2016; 66: 27-33. http://dx.doi.org/10.1016/j.lwt.2015.10.016

Abdullah N, Ismail SM, Aminudin N, et al. Evaluation of selected culinary-medicinal mushrooms for antioxidant and ace inhibitory activities. Evid Based Complement Alternat Med 2012; 2012: 1-12. http://dx.doi.org/10.1155/2012/464238

Kettawan A, Chanlekha K, Kongkachui R, et al. Effects of cooking on antioxidant activities and polyphenol content of edible mushrooms commonly consumed in Thailand. Pak J Nutr 2011; 10(11): 1094-103. http://dx.doi.org/10.3923/pjn.2011.1094.1103

Saad WZ, Hashim M, Ahmad S, et al. Effects of heat treatment on total phenolic contents, antioxidant and antiinflammatory activities of Pleurotus sajor-caju extract. Int J Food Prop 2011; 17(1): 219-25. http://dx.doi.org/10.1080/10942912.2011.619290

Kim JH, Kim SJ, Park HR, et al. The different antioxidant and anticancer activities depending on the colour of oyster mushrooms. J Med Plant Res 2009; 3: 1016–2020. [cited 2018 June 8]: Available from http://www.academicjournals.org/JMPR

Tan Y, Baskaran A, Nallathamby N, et al. Influence of customized cooking methods on the phenolic contents and antioxidant activities of selected species of oyster mushrooms (Pleurotus spp.). J Food Sci Technol 2014; 52(5): 3058-64. http://dx.doi.org/10.1007/s13197-014-1332-8

Roncero-Ramos I, Mendiola-Lanao M, Pérez-Clavijo M, et al. Effect of different cooking methods on nutritional value and antioxidant activity of cultivated mushrooms. Int J Food Sci Nutr 2016; 68(3): 287-97. http://dx.doi.org/10.1080/09637486.2016.1244662

Manzi P, Marconi S, Aguzzi A, et al. Commercial mushrooms: nutritional quality and effect of cooking. Food Chem 2004; 84(2): 201-6. http://dx.doi.org/10.1016/S0308-8146(03)00202-4

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2018-09-24

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Enshasy, H. A. E.-., Selvamani, S., Dailin, D. J., Malek, R. A., Hanapi, S. Z., Ambehabati, K. K., Sukmawati, D., Leng, O. M., & Moloi, N. (2018). Antioxidant Compounds of the Edible Mushroom Pleurotus ostreatus. International Journal of Biotechnology for Wellness Industries, 7, 1–14. https://doi.org/10.6000/1927-3037.2018.07.01

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