Serum Level of Calcium, Phosphorus and 25 OH Vitamin D in Neo-nates with Indirect Hyperbilirubinemia Treated with Phototherapy
DOI:
https://doi.org/10.6000/1929-4247.2026.15.04.1Keywords:
Hyperbilirubinemia, phototherapy, neonatesAbstract
Background: Phototherapy is the standard treatment for neonatal indirect hyperbilirubinemia. However, it may affect calcium-phosphorus metabolism and vitamin D status in neonates.
Objective: To evaluate changes in serum calcium, phosphorus, and 25-hydroxyvitamin D levels after phototherapy in neonates with indirect hyperbilirubinemia.
Methods: An observational prospective study was conducted over six months at Ain Shams University hospitals. Sixty neonates with indirect hyperbilirubinemia requiring phototherapy were included. Total and direct bilirubin, serum calcium, phosphorus, and serum 25 OH vitamin D were measured before initiation and after 48 hours of phototherapy.
Results: Phototherapy significantly reduced total serum bilirubin. However, it was also associated with a decline in serum calcium and phosphorus levels. Additionally, vitamin D levels increased.
Conclusion: Phototherapy effectively reduced bilirubin levels but was associated with decreased serum calcium and phosphorus levels and increased serum 25-hydroxyvitamin D levels. Monitoring of mineral status during phototherapy may therefore be beneficial.
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