HIV Sero-Prevalence among Infants Attending Immunization Centers in Calabar Metropolis, Cross River State, Southern, Nigeria

Authors

  • Venn J. Ifeoma Department of Pediatrics, University of Calabar, Calabar,
  • Ochigbo O. Sunday Department of Pediatrics, University of Calabar, Calabar,
  • Anah U. Maxwell Department of Pediatrics, University of Calabar, Calabar,
  • Asindi Asindi Asindi Department of Pediatrics, University of Calabar, Calabar,

DOI:

https://doi.org/10.6000/1929-4247.2016.05.03.5

Keywords:

DBS, HIV, Infants, DNA PCR, PMTCT, ARV.

Abstract

Introduction: Pediatric Human Immunodeficiency Virus (HIV) infection accounts for over 2.3% of all pediatric infections. Many HIV-infected infants are not identified until they develop symptoms and present with illness at health facilities. However, the six weeks immunization visit provides an opportunity for HIV-infected mothers and their exposed infants to be identified before symptoms occur. This study was therefore conducted to determine the HIV status of infants attending immunization clinics in Calabar with a view to enrolling them into treatment.

Subjects and Method: This cross sectional descriptive study was conducted in two Local Government Areas of Calabar consisting 22 selected immunization centers. Using the multistage sampling method, 330 infants were screened. Ethical clearance was obtained from the supervising Ministry of Health. Rapid test was conducted, reactive specimens had Deoxyribonucleic Acid Polymerase Chain Reaction (DNA PCR) done using Dried Blood Spots (DBS).

Results: A total of 330 infants aged 6 to 14 weeks were recruited, 173 (52.4%) were males while 157(47.6%) were females giving male to female ratio of 1.1:1. Mean age of the infants was 9.20 ± 3.1 weeks. Twenty four (24) tested positive for HIV antibodies, after HIV DNA PCR test, 14(4.2%) infants were infected. Antenatal care registration (ANC) and maternal ANC HIV status were statistically significant P=0.03 and P= 0.02 respectively.

Conclusion: HIV exposed and infected infants are still been missed and only diagnosed later in life. Therefore, maternal HIV status determination and early diagnosis at immunization centers is recommended to bridge the Prevention of Mother To child Transmission (PMTCT) gap.

References

[1] Tindyebwa D, Kayita J, Musoke P, Eley B, Nduati R, Tumwesigye N, et al., Eds. Handbook of Paediatric AIDS in Africa. 2nd ed. Kampala: ANECCA 2011; pp. 3-33.
[2] Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 2015; 385: 430-40.
http://dx.doi.org/10.1016/S0140-6736(14)61698-6
[3] Fapohunda BM, Orobaton NG. When women deliver with no one present in Nigeria: who, what, where and so what? Plos One 2013; 8: e69569.
http://dx.doi.org/10.1371/journal.pone.0069569
[4] Federal Republic of Nigeria. Global AIDS response progress report, Nigeria. Abuja: National action committee on AIDS 2014; P33-8.
[5] Sinunu MA, Schouten EJ, Wadonda-Kabondo N, et al. Evaluating the impact of prevention of mother-to-child transmission of HIV in Malawi through immunization clinic-based surveillance. PLoS One 2014; 9: e100741.
[6] Burr CK, Lampe MA, Corle S, et al. An end to perinatal HIV: Success in the US requires ongoing and innovative efforts that should expand globally. J Public Health Policy 2007; 28: 249-60.
http://dx.doi.org/10.1057/palgrave.jphp.3200126
[7] Okeudo C, Ezem B, Ojiyi E. Mother-to-child transmission rate of HIV at orlu, south-eastern Nigeria. Int J Gyneco Obstet 2012; 16: 2.
[8] Bloemen S. Early infant HIV diagnosis helps save lives in Malawi. Available via unicef.org/infobycountry/malawi_ 46696.html. 2013.
[9] National Bureau of Statistics. Multiple indicator cluster Survey Report 2013: monitoring the situation of children. Abuja: National Bureau of Statistics 2013; pp. 48-51.
[10] Sadoh AE, Eregie C. Timeliness and completing rate of immunization among Nigerian children attending clinic based immunization service. J Health Popul Nutr 2009; 27: 391-5.
http://dx.doi.org/10.3329/jhpn.v27i3.3381
[11] Udo JJ, Ntia HU, Anah MU, Eyong KI, Ewa AU, Etuk IS. HIV seroprevalence in children whose mothers were seronegative at antenatal care booking in an immunization centre in Calabar, Nigeria. Pediatr Infect Dis J 2013; 8: 83-6.
[12] Federal Ministry of Health Nigeria. Integrated National guidelines for HIV prevention, treatment and care. Abuja: Federal Ministry of health Nigeria 2014; pp. 20-32.
[13] Lamias MJ. Maternal and Perinatal risk factors associated with vertical transmission of hiv-1 infection from mother to child. Am J Trop Hyg 2014; 90: 902-7.
[14] Edathodu J, Halim MM, Dahham MB, Alrajhi AA. Mother-to-child transmission of HIV: experience at a referral hospital in Saudi Arabia. Ann Saudi Med 2010; 30: 15-7.
[15] Berhan, Z., Abebe, F., Gedefaw, M, Tesfa, M. Prevalence of HIV and associated factors among infants born to HIV positive women in Amhara region, Ethiopia. Int J Clin Med 2014; 5: 464-74.
http://dx.doi.org/10.4236/ijcm.2014.58065
[16] Bucagu M, Muganda J. Implementing primary health care –based PMTCT interventions: Operational perspectives from Muhima cohort analysis (Rwanda). Pan Afr Med J 2014; 18: 59.
http://dx.doi.org/10.11604/pamj.2014.18.59.3895
[17] Horwood C, Haskins L, Vermaak K, Phakathi S, Subbaye R, Doherty T. Prevention of mother to child transmission of HIV programme in KwaZulu-Natal, South Africa: an evaluation of PMTCT implementation and integration into routine maternal, child and women's health services. Trop Med Int Health 2010; 15: 992-9.
http://dx.doi.org/10.1111/j.1365-3156.2010.02576.x
[18] Nigeria Demographic Health Survey. National Population Commission, Federal Republic of Nigeria. ICF International Rockville, Maryland, USA 2014.
[19] Manji KP, Dugann C, Liu E, et al. Exclusive Breast feeding protects against MTCT of HIV though 12 months of age in Tanzania. J Trop Paediatr 2016.

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Published

2016-09-02

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General Articles