Interaction between T Cells and Endothelial Cells: Insights into Immune Response and Vascular Health among Children

Authors

  • Yousef Hawsawi Research Center, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
  • Shmoukh Alotaibi Research Center, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia
  • Badi Alanazi The Yammam Hospital for Women and Children, Riyadh, Saudi Arabia
  • Abeer Alsofyani King Abdullah International Medical Research Center (KAIMRC) King Saud bin Abdulaziz University for Health Sciences (KSAU-HS) Jeddah, Saudi Arabia
  • Talat Bukhari Department of Immunology, College of Medicine, Um Qura University, Makkah, Saudi Arabia
  • Abdulmajeed Alanazi MOH Centers, Riyadh, Saudi Arabia
  • Wafa Alanazi MOH Centers, Riyadh, Saudi Arabia
  • Majed Alanazi MOH Centers, Riyadh, Saudi Arabia
  • Faisal M. Alanazi MOH Centers, Riyadh, Saudi Arabia
  • Meaad Alanazi KAMC, Riyadh, Saudi Arabia
  • Aiysha Alanazi KAMC, Riyadh, Saudi Arabia
  • Fahad Alanazi Forensic Med Center Riyadh, Saudi Arabia
  • Abdulrahman Alanazi Alnakheek Health Center, Riyadh, Saudi Arabia
  • Essa E. Alanazi Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Manal K. Almasaud Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Ahmed A. Albloi Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Ali M. Masawi Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Hussain A.A. Altariqi Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Ali I. Alameer Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Reem M.M. Altawier Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Amal M. AlZayer Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Abdulrahman A.A. Altariqi Riyadh Regional Laboratory, MOH, Riyadh, Saudi Arabia
  • Awal Zaki Dammam Regional Lab, Dammam, Saudi Arabia
  • Mohammed A. Alshehri Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam University, Alkharj (PSAU), Alkharj, Saudi Arabia
  • Abdullah Alghamdi Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam University, Alkharj (PSAU), Alkharj, Saudi Arabia
  • Faris Q.B. Alenzi Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam University, Alkharj (PSAU), Alkharj, Saudi Arabia

DOI:

https://doi.org/10.6000/1929-4247.2024.13.01.5

Keywords:

T cells, endothelial cells, vitamin c, zinc, omega fatty acids, nutrition and health

Abstract

The functioning of T cells, key players in the immune response, is inherently influenced by specific nutrients. Understanding how dietary factors influence T cell function is pivotal in the context of child health. Eendothelial cell antigen presentation to T cells influences the outcome of several immune system functions. However, the consequences of these interactions are still discussed, with different responses observed depending on the phenotype and functional reactivity of both cells. Relating our findings to specific nutrition-related diseases in children, such as obesity, diabetes, and cardiovascular issues, establishes a direct link between T cell-endothelium interactions and pediatric health outcomes. The role of nutritional interventions extends beyond meeting basic dietary needs; it plays a dynamic role in shaping immune responses in children. Recognizing the interconnectedness of nutrition and immunology allows for developing targeted strategies. In this study, we find a close relationship between T lymphocytes (CTL) and endothelium, which is required and important for proliferation and differentiation to determine the size of the cell mass in the circulation. With an eye towards therapeutic opportunities, this review discusses in detail the link between both, how they are each activated, their substrates, and their regulation, and maps out how they interact.

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Published

2024-03-25

How to Cite

Hawsawi, Y. ., Alotaibi, S. ., Alanazi, B. ., Alsofyani, A. ., Bukhari, T. ., Alanazi, A. ., Alanazi, W. ., Alanazi, M. ., Alanazi, F. M. ., Alanazi, M. ., Alanazi, A. ., Alanazi, F. ., Alanazi, A. ., Alanazi, E. E. ., Almasaud, M. K. ., Albloi, A. A. ., Masawi, A. M. ., Altariqi, H. A. ., Alameer, A. I. ., Altawier, R. M. ., AlZayer, A. M. ., Altariqi, A. A. ., Zaki, A. ., Alshehri, M. A. ., Alghamdi, A. ., & Alenzi, F. Q. . (2024). Interaction between T Cells and Endothelial Cells: Insights into Immune Response and Vascular Health among Children. International Journal of Child Health and Nutrition, 13(1), 47–54. https://doi.org/10.6000/1929-4247.2024.13.01.5

Issue

Vol. 13 No. 1 (2024)

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General Articles

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