Association between Obesity, Race and Knee Osteoarthritis: The Multicenter Osteoarthritis Study
DOI:
https://doi.org/10.6000/1929-6029.2014.03.03.2Keywords:
Body mass index, Cumulative logits, Kellgren-Lawrence (KL) grade, Knee radiograph, Longitudinal ordinal data, Mixed effects model, Proportional odds model, Risk factorsAbstract
On the basis of longitudinal Kellgren-Lawrence (KL) grades of knee radiographs obtained from the Multicenter Osteoarthritis Study (MOST), we examine the association of obesity and race with severity of knee osteoarthritis (OA). We use the proportional odds model with mixed effects to conduct the analysis. Repeated KL grades were modeled as ordinal longitudinal measures, and a random effect term was included to adjust for the within-subject correlation among the KL grades over time. We found that African Americans and more obese participants in MOST have a greater risk of developing severe knee OA.
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Copyright (c) 2014 Xin He, Xiaoxiao Lu, Shuo Chen, Marc C. Hochberg, Mei-Ling Ting Lee
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