Cancer Growth Inhibition Using Predictive Mathematical Models of Signaling Pathways
DOI:
https://doi.org/10.6000/1929-6029.2021.10.12Keywords:
Cancer Growth, Modeling, Signaling Pathways, Predictive Mathematical ModelsAbstract
Cancer cells develop several hallmark changes over the progress of the tumor process. Cell assistance in multicellular organisms is regulated by the division of cell coordination by aggressive growth modulation. In this perspective, the use of molecular indicators triggering cell division is a mystery, because a cancer cell can manipulate any molecule that induces and helps growth, disturbing cellular assistance. An effective alteration proceeding to tumors must develop to be competitive, allowing a cancer cell to pass a signal resulting in better selection chances. The subjective simulation of physiological systems has become increasingly valuable in recent years, and there is now a wide range of mathematical models of signalling pathways that have contributed to some groundbreaking discoveries and hypotheses as to how this system works. Here we discuss various modeling methods and their application to the physiology of medical systems, focusing on the identification of parameters in ordinary differential equation models and their significance for forecasting cellular decisions in network modeling. In situations of global and local cell-to-cell rivalry, we quantify how this mechanism impacts a mutated cell's fixing chance of producing such a signal, and consider that this process will play a vital role in reducing cancer.
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