Controlled Release of Tramadol from Mixed Matrix Membranes

Authors

  • L. Donato National Research Council - Institute for Membrane Technology (ITM–CNR), c/o The University of Calabria, cubo 17C, Via Pietro BUCCI, 87036 Rende CS, Italy
  • G. Barbaro National Research Council - Institute for Membrane Technology (ITM–CNR), c/o The University of Calabria, cubo 17C, Via Pietro BUCCI, 87036 Rende CS, Italy
  • E. Drioli National Research Council - Institute for Membrane Technology (ITM–CNR), c/o The University of Calabria, cubo 17C, Via Pietro BUCCI, 87036 Rende CS, Italy
  • Catia Algieri National Research Council - Institute for Membrane Technology (ITM–CNR), c/o The University of Calabria, cubo 17C, Via Pietro BUCCI, 87036 Rende CS, Italy

DOI:

https://doi.org/10.6000/1929-6037.2012.01.02.8

Keywords:

Tramadol hydrochloride, transdermal drug delivery, polydimethylsiloxane, FAU zeolite, NaX-PDMS membranes

Abstract

In this work mixed matrix membranes (zeolite loaded) were prepared and tested as potential devices for the controlled release of tramadol hydrochloride. Due to the hydrophilic nature of the drug, a hydrophobic polymer (polydimethylsiloxane) was chosen for the membrane preparation. NaX zeolites was added to PDMS matrix as modulating agent with the aim to obtain a linear and adequate delivery of the drug in the time as required by the therapeutic needs of this opioid.

About the different investigated systems, the PDMS membrane containing 17 wt% of zeolite and 0.2 wt% of drug seems to be the most promising for application as transdermal device. Different mathematical models (Zero order, First order, Higuchi, Bhaskar, and Korsemeyer-Peppas) were used to interpret the drug release mechanism from the different Mixed matrix membranes. The experimental data showed good fit with three different models: Higuchi, Bhaskar and Korsemeyer-Peppas.

References

Uchegbu IF, Schätzlein AG, Polymers in Drug Delivery. CRC press, Taylor & Francis Group New York 2006; pp. 377-407.

Lawrence EL, Turner IG. Materials for urinary catheters: a review of their history and development in the U. Med Eng Phys 2005; 27: 443-53. http://dx.doi.org/10.1016/j.medengphy.2004.12.013

Saito Y, Inamura H. Airway stenting. Surg Today 2005; 35: 267-70. http://dx.doi.org/10.1007/s00595-004-2942-y

Stamatialis DF, Papenburg BJ, Girones M, Saiful S, Bettahalli SNM, Schmitmeier S, et al. Medical applications of membranes: drug delivery, artificial organs and tissue engineering. J Membr Sci 2008; 308: 1-34. http://dx.doi.org/10.1016/j.memsci.2007.09.059

Sullad AG, Manjeshwar LS, Aminobhavi TM. Controlled release of theophylline from interpenetrating blend microspheres of poly(vinyl alcohol) and methyl cellulose. J Appl Polym Sci 2010; 116: 1226-35.

Limpongsa E, Umprayn K. Preparation and evaluation of diltiazem hydrochloride diffusion-controlled transdermal delivery system. AAPS PharmSciTech 2008; 9: 464. http://dx.doi.org/10.1208/s12249-008-9062-8

Subedi RK, Oh SY, Chun MK, Choi HK. Recent Advances in transdermal drug delivery. Arch Pharm Res 2010; 33: 339-51. http://dx.doi.org/10.1007/s12272-010-0301-7

Rimoli MG, Rabaioli MR, Melisi D, Curcio A, Mondello S, Mirabelli R, et al. Synthetic zeolites as a new tool for drug delivery. J Biomed Mater Res A 2007; 87A: 156-64. http://dx.doi.org/10.1002/jbm.a.31763

Martinez C, Corma A. Inorganic molecular sieves: Preparation, modification and industrial application in catalytic processes. Coord Chem Rev 2011; 255: 1558-80. http://dx.doi.org/10.1016/j.ccr.2011.03.014

Fruijtier-Pölloth C. The safety of synthetic zeolites used in detergents. Arch Toxicol 2009; 83: 23-25. http://dx.doi.org/10.1007/s00204-008-0327-5

De Gennaro M, Cerri G. Pharmaceutical zeolite-based compositions containing zinc and erythromycin, to be used in the treatment of acne. Patent: WO 02/100420; 2002.

Dyer A, Morgan S, Welles P, Williams C. The use of zeolites as slow release anthelmintic carriers. J Helminthol 2000; 74: 137-41.

Clarizia G, Algieri C, Drioli E. Filler-polymer combination: a route to modify gas transport properties of a polymeric membrane. Polymer 2004; 45: 5671-81. http://dx.doi.org/10.1016/j.polymer.2004.06.001

Clarizia G, Algieri C, Regina A, Drioli E. Zeolite-based composite membranes: gas transport and surface properties. Micropor Mesopor Mat 2008; 115: 67-74. http://dx.doi.org/10.1016/j.micromeso.2008.01.048

Chung TS, Jiang LY, Li Y, Kulprathipanja S. Mixed matrix membranes (MMMs) comprising organic polymers with dispersed inorganic fillers for gas separation. Prog Polym Sci 2007; 32: 483-507. http://dx.doi.org/10.1016/j.progpolymsci.2007.01.008

Aroon MA, Ismail AF, Matsuura T, Montazer-Rahmati MM. Performance studies of mixed matrix membranes for gas separation: A review. Sep Purif Technol 2010; 75: 229-42. http://dx.doi.org/10.1016/j.seppur.2010.08.023

Coluzzi F, Mattia C. Chronic non-cancer pain: Focus on once-daily tramadol formulations. Ther Clin Risk Manage 2007; 3(5): 819-29.

Salsa T, Veiga F, Pina ME. Oral controlled-release dosage forms. I. Cellulose ether polymers in hydrophilic matrices. Drug Dev Ind Pharm 1997; 23: 929-38. http://dx.doi.org/10.3109/03639049709148697

Mulder M. Basic Principles of Membrane Technology, Ed. Kluwer Academic Publishers, London 1991; p. 59.

Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs 2000; 60(1): 139-76. http://dx.doi.org/10.2165/00003495-200060010-00008

Acosta N, Aranaz I, Peniche C, Heras A. Tramadol reelase from a delivery system based on alginate-chitosan microcapsules. Macromol Biosci 2003; 3: 546-51. http://dx.doi.org/10.1002/mabi.200300009

Mishra B, Bakde BV, Singh PN, Kumar P. Development and in-vitro evaluation of oral sustained release formulation of tramadol hydrochloride. Acta Pharma Sci 2006; 48: 153-66.

Breck DW. Zeolite Molecular Sieves. Wiley, New York 1974.

Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modelling on drug release from controlled drug delivery systems. Acta Pol Pharm-Drug Res 2010; 67: 217-23.

Freitas MN, Marchetti JM. Nimesulide PLA microspheres as a potential sustained release system for the treatment of inflammatory diseases. Int J Pharm 2005; 295: 201-11. http://dx.doi.org/10.1016/j.ijpharm.2005.03.003

Higuchi TJ. Mechanism of sustained medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. Pharm Sci 1963; 84: 1464-77.

Shoaib HM, Tazeen J, Merchant AH, Yousuf IR. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. J Pharm Sci 2006; 19: 119-24.

Bhaskar R, Murthy RSR, Miglani BD, Viswanathan K. Novel method to evaluate diffusion controlled release of drug from resinate. Int J Pharm 1986; 28: 59-66. http://dx.doi.org/10.1016/0378-5173(86)90147-X

Ambrogi V, Fardella G, Grandolini G, Perioli L, Tiralti MC. Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents, II: uptake of diclofenac for a controlled release formulation. AAPS Pharm Sci Tech 2002; 3(3): 1-6. http://dx.doi.org/10.1007/BF02830624

Prasanthi NL, Manikiran SS, Rama Rao N. Effect of solubility of the drug on the release kinetics from hydrophilic matrices. Int J Pharm Tech Res 2010; 2: 2506-11.

Vankelecom IFJ, Scheppers E, Heus R, Uytterhoeven JB. Parameters influencing zeolite incorporation in PDMS membranes. J Phys Chem 1994; 98: 12390-96. http: //www.rxlist.com/duragesic-drug.htm. http://dx.doi.org/10.1021/j100098a038

Horcajada P, Márquez-Alvarez C, Ràmila A, Pérez-Pariente J, Vallet-Regì M. Controlled release of Ibuprofen from dealuminated faujasite. Solid State Sci 2006; 8: 1459-65. http://dx.doi.org/10.1016/j.solidstatesciences.2006.07.016

Ma D, McHugh AJ. The interplay of phase inversion and membrane formation in the drug release characteristics of a membrane-based delivery system. J Membr Sci 2007; 298: 156-68. http://dx.doi.org/10.1016/j.memsci.2007.04.013

Downloads

Published

2012-12-31

How to Cite

Donato, L., Barbaro, G., Drioli, E., & Algieri, C. (2012). Controlled Release of Tramadol from Mixed Matrix Membranes. Journal of Membrane and Separation Technology, 1(2), 137–144. https://doi.org/10.6000/1929-6037.2012.01.02.8

Issue

Section

Articles