Boron in Human Nutrition and its Regulations Use

Laura Dinca; Romulus Scorei

doi:10.6000/1929-5634.2013.02.01.3

Authors

Laura Dinca University of Craiova, Faculty of Economics and Business Administration, Department of Management & Marketing, Craiova, Romania
Romulus Scorei University of Craiova, Faculty of Horticulture, Bioboron Research Institute, Craiova, Romania

DOI:

https://doi.org/10.6000/1929-5634.2013.02.01.3

Keywords:

Nutraceuticals, dietary supplements, boron, nutrition, regulations

Abstract

According to the literature, there are increasingly more scientific data regarding the boron importance in the human nutrition. The request for boron supplements has become more significant due to the following two discoveries: boron transport within the animal cell and the cellular signaling of some bacteria by a sugar borate complex. It is necessary to establish the benefits and the toxicity of boron consumption for humans and animals, although a biological function of boron has not been defined yet. In addition, it is important to know the legal regulations for boron use worldwide, its physiological effects and health uses.

Author Biography

Laura Dinca, University of Craiova, Faculty of Economics and Business Administration, Department of Management & Marketing, Craiova, Romania

References

Dembitsky VM, Smoum R, Al-Quntar AAA, Ali HA, Pergament I, Srebnik M. Natural occurrence of boron-containing compounds in plants, algae and microorganisms. Plant Sci 2002; 163: 931-42. http://dx.doi.org/10.1016/S0168-9452(02)00174-7

Loomis WD, Durst RW. Chemistry and Biology of Boron. BioFactors 1992; 3: 229-39.

Hunt CD. Dietary boron: Progress in establishing essential roles in human physiology. J Trace Elem Exp Med 2012; 26: 157-60. http://dx.doi.org/10.1016/j.jtemb.2012.03.014

Scorei R. Is boron a prebiotic element? A mini-review of the essentiality of boron for the appearance of life on Earth. Orig Life Evol Biosph 2012; 42(1): 3-17. http://dx.doi.org/10.1007/s11084-012-9269-2

Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelezer I, Bassler BL, Hughson FM. Structural identification of a bacterial quorum-sensing signal containing boron. Nature 2002; 415: 545-49. http://dx.doi.org/10.1038/415545a

Park M, Li Q, Shcheynikov N, Muallen S, Zeng W. NaBC1 is a ubiquitous electrogenic Na+-coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell 2004; 16 (3): 331-41. http://dx.doi.org/10.1016/j.molcel.2004.09.030

Dembitsky VM, Al-Quntar AAA, Srebnik M. Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing. Chem Rev 2011; 111: 209-37. http://dx.doi.org/10.1021/cr100093b

Hunt CD. Boron. In: Encyclopedia of dietary supplements. 2nd Ed. New York, London: Informa Healthcare 2010; pp. 82-90.

Nieves JW. Skeletal effects of nutrients and nutraceuticals, beyond calcium and vitamin D. Osteoporos Int 2012; Nov 14. http://dx.doi.org/10.1007/s00198-012-2214-4

Biesalski HK. Nutraceuticals: the link between nutrition and medicine. In: Nutraceuticals in health and disease prevention. Kramer K, Hoppe PP, Packer L, Eds. New York: Marcel Dekker Inc. 2001; pp. 1-26. http://dx.doi.org/10.1201/9780203908174.ch1

Zeisel SH. Regulation of "Nutraceuticals”. Science 1999; 285: 185-186. http://dx.doi.org/10.1126/science.285.5435.1853

Gulati OP, Ottaway PB. Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products. Toxicol 2006; 221: 75-87. http://dx.doi.org/10.1016/j.tox.2006.01.014

EU Commission (2003) Proposal for a Regulation of the European Parliament and of the Council on Nutrition and Health Claims Made on Foods. COM 0165 dated 16.07.2003; pp. 11-19.

Reuterswärd AL. The new EC Regulation on nutrition and health claims on foods. Scand J Food Nutr 2007; 51(3): 100-106. http://dx.doi.org/10.1080/17482970701685625

Meacham S, Karakas S, Wallace A, Altun F. Boron in Human Health: Evidence for Dietary Recommendations and Public Policies. OMPJ 2010; 3: 36-53.

Scorei R, Popa R. Boron-containing compounds as preventive and chemotherapeutic agents for cancer. AntiCancer Agents Med Chem 2010; 10: 346-51. http://dx.doi.org/10.2174/187152010791162289

Devirian TA, Volpe SL. The physiological effects of dietary boron. Crit Rev Food Sci Nutr 2003; 43(2): 219-31. http://dx.doi.org/10.1080/10408690390826491

Becking GC, Chen B-H (International programme on chemical safety (IPCS) environmental health criteria on boron human health risk assessment. Biol Trace Elem Res 1998; 66(1-3): 439-50. http://dx.doi.org/10.1007/BF02783154

Rainey CJ, Nyquist LA. Multicountry estimation of dietary boron intake. Biol Trace Elem Res 1998; 66: 79-86. http://dx.doi.org/10.1007/BF02783128

Richold M. Boron Exposure from consumer products. Biol Trace Elem Res 1998; 66: 121-29. http://dx.doi.org/10.1007/BF02783132

Rainey CJ, Nyquist LA, Christensen RE, Strong PL, Culver BD, Coughlin JR. Daily boron intake from the American diet. J Am Diet Assoc 1999; 99: 335-40. http://dx.doi.org/10.1016/S0002-8223(99)00085-1

Bakirdere S, Örenay S, Korkmaz M. Effect of Boron on Human Health. OMPJ 2010; 3: 54-59.

Nielsen FH. Is boron nutritionally relevant? Nutr Rev 2008; 66(4): 183-91. http://dx.doi.org/10.1111/j.1753-4887.2008.00023.x

EPA (United State Environmental Protection Agency). Health Effects Support Document for Boron. 2008; Available from: http://www.epa.gov/ogwdw/ccl/pdfs/reg_determine2/healtheffects_ccl2-reg2_boron.pdf

SCCS (Scientific Committee on Consumer Safety). Opinion on boron compounds. 22 June 2010; Avalaible from: http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_027.pdf

EFSA (European Food Safety Authority). Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the Tolerable Upper Intake Level of Boron (Sodium Borate and Boric Acid). EFSA Journal 2004; 80: 1-22.

Woods WG. Review of possible boron speciation relating to its essentiality. J Trace Elem Exp Med 1996; 9(4): 153-63. http://dx.doi.org/10.1002/(SICI)1520-670X(1996)9:4<153::AID-JTRA3>3.0.CO;2-S

Miljkovic D, Scorei IR, Cimpoiasu VM, Scorei ID. Calcium fructoborate: plant based dietary boron for human nutrition. J Diet Suppl 2009; 6: 211-26. http://dx.doi.org/10.1080/19390210903070772

Scorei RI, Rotaru P. Calcium Fructoborate - Potential anti-inflammatory agent. Biol Trace Elem Res 2011; 143 (3): 1223-38. http://dx.doi.org/10.1007/s12011-011-8972-6

Nielsen FH, Meacham S. Growing evidence for human health benefits of boron. JEBCAM 2011; 16: 169-80. http://dx.doi.org/10.1097/00017285-199205000-00003

Scorei R. Regulation of therapeutic potential of boron-containing compounds. In: Kretsinger H, Uversky VN, Permyakov EA, Eds. Encyclopedia of Metalloproteins. Springer 2013; 1400: p. 100 illus.

Nielsen FH. Facts and fallacies about boron. Nutr Today 1992; 27: 6-12.

Nielsen FH. Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Perspect 1994; 102(7): 59-63. http://dx.doi.org/10.1289/ehp.94102s759

Benderdour M, Hess K, Dzondo-Gadet M, Nabet P, Belleville F, Dousset B. Boron modulates extracellular matrix and TNF alpha synthesis in human fibroblasts. Biochem Biophys Res Commun 1998; 246(3): 746-51. http://dx.doi.org/10.1006/bbrc.1998.8688

McCoy H, Kenney MA, Montgomery C, Irwin A, Williams L, Orrell R. Relation of boron to the composition and mechanical properties of bone. Environ Health Perspect 1994; 102(7): 49-53. http://dx.doi.org/10.1289/ehp.94102s749

Hunt CD. The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect 1994; 102(7): 35-43. http://dx.doi.org/10.1289/ehp.94102s735

Hunt CD. Biochemical effects of physiological amounts of dietary boron. J Trace Elem Exp Med 1996; 9: 185-13. http://dx.doi.org/10.1002/(SICI)1520-670X(1996)9:4<185::AID-JTRA6>3.0.CO;2-Q

Rowe RI, Eckhert CD. Boron is required for zebrafish embryogenesis. J Exp Biol 1999; 202(12): 1649-54.

Fort DJ. Boron deficiency disables Xenopus laevis oocyte maturation events. Biol Trace Elem Res 2002; 85(2): 157-69. http://dx.doi.org/10.1385/BTER:85:2:157

Lanoue L, Taubeneck MW, Muniz J, Hanna LA, Strong PL, Murray FJ, Nielsen FH, Hunt CD, Keen CL. Assessing the effects of low boron diets on embryonic and fetal development in rodents using in vitro and in vivo model systems. Biol Trace Elem Res 1998; 66(1-3): 271-98. http://dx.doi.org/10.1007/BF02783143

Meacham SL, Taper LJ, Volpe SL. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environ Health Perspect 1994; 102: 79-82.

Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Prospect 1994; 102(7): 83-85. http://dx.doi.org/10.1289/ehp.94102s783

Scorei R, Mitrut P, Petrisor I, Scorei ID. A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. Biol Trace Elem Res 2011; 144(1-3): 253-63. http://dx.doi.org/10.1007/s12011-011-9083-0

Cheng J, Peng K, Jin E, Zhang Y, Liu Y, Zhang N, et al. Effect of additional boron on tibias of African ostrich chicks. Biol Trace Elem Res 2011; 144(1-3): 538-49. http://dx.doi.org/10.1007/s12011-011-9024-y

Hosmane NS, Ed. Boron Science: New Technologies and Applications. CRC Press, Northern Illinois University, Dekalb, USA 2011. http://dx.doi.org/10.1201/b11199

Baker SJ, Tomshob JW, Benkovicc SJ. Boron-containing inhibitors of synthetases. Chem Soc Rev 2011; 40: 4279-85. http://dx.doi.org/10.1039/c0cs00131g

Ishii Y, Fujizuka N, Takahashi T, Shimizu K, Tuchida A, Yano S, et al. A fatal case of acute boric acid poisoning. Clin Toxicol 1993; 31(2): 345-52. http://dx.doi.org/10.3109/15563659309000402

Culver BD, Hubbard SA. Inorganic boron health effects in humans: an aid to risk assessment and clinical judgment. J Trace Elem Exp Med 1996; 9: 175-84. http://dx.doi.org/10.1002/(SICI)1520-670X(1996)9:4<175::AID-JTRA5>3.0.CO;2-Q

Craan AG, Myres AW, Green DW. Hazard assessment of boric acid in toys. Reg Tox Pharm 1997; 26: 271-80. http://dx.doi.org/10.1006/rtph.1997.1155

Linden CA, Alan AH, Kulig KW, Rumack BH. Acute ingestion of boric acid. Clin Toxicol 1986; 24: 260-79. http://dx.doi.org/10.3109/15563658608992592

Garabrant DH, Bernstein L, Peters JM, Smith TJ. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984; 26: 584-86. http://dx.doi.org/10.1097/00043764-198408000-00013

Teshima D, Morishita K, Ueda Y, Futagami K, Higuchi S, Komoda T, et al. Clinical management of boric acid ingestion: pharmacokinetic assessment of efficacy of hemodialysis for treatment of acute boric acid poisoning. J Pharmacobiodyn 1992; 15(6): 287-94. http://dx.doi.org/10.1248/bpb1978.15.287

Pahl MV, Culver BD, Vaziri ND. Boron and the kidney. J Ren Nutr 2005; 15(4): 362-70. http://dx.doi.org/10.1053/j.jrn.2005.05.001

Pinto J, Huang YP, McConnell RJ, Rivlin RS. Increased urinary riboflavin excretion resulting from boric acid ingestion. J Lab Clin Med 1978; 92(1): 126-34.

Scorei R, Ciubar R, Ciofrangeanu CM, Mitran V, Cimpean A, Iordachescu D. Comparative effects of boric acid and calcium fructoborate on breast cancer cells. Biol Trace Elem Res 2008; 122: 197-205. http://dx.doi.org/10.1007/s12011-007-8081-8

Scorei R. Boron Compounds in the Breast Cancer Cells. Chemoprevention and Chemotherapy. In: Breast Cancer - Current and Alternative Therapeutic Modalities ISBN 978 953-307-776-5 Edited by: Esra Gunduz and Mehmet Gunduz InTech 2011; pp. 92-114.

Park M, Li Q, Shcheynikov N, Muallen S, Zeng W. Borate transport and cell growth and proliferation: not only in plants. Cell Cycle 2005; 4(1): 24-26. http://dx.doi.org/10.4161/cc.4.1.1394

Barranco WT, Eckhert CD. Boric acid inhibits human prostate cancer cell proliferation. Cancer Lett 2004; 216(1): 21-29. http://dx.doi.org/10.1016/j.canlet.2004.06.001

Scorei RI, Popa R. Sugar-Borate Esters-Potential Chemical Agents in Prostate Cancer Chemoprevention. AntiCancer Agents Med Chem 2013; (in press).

EC (European Commission. Scientific Committee on Food). Tolerable Upper Intake Levels for Vitamins and Minerals.2006. Avalilable from:http://ec.europa. eu/comm./food/fs/sc/scf/out80 en.htm.

Commission Regulation (EU) No. 1129/2011 amending Annex II to Regulation (EC) No. 1333/2008 of the European Parliament and of the Council by establishing a Union list of food additives (OJ No. L 295, 12.11.2011, p. 1) (“Regulation 1129/2011”)

EFSA (European Food Safe Authorithy). Scientific Opinion on the substantiation of health claims related to boron and prevention and treatment of prostate cancer (ID 221), maintenance of normal thyroid function (ID 222) and contribution to normal cognitive function (ID 223) pursuant to Article 13(1) of Regulation (EC) No 1924/20061. EFSA Journal 2011; 9(6): 2209, 1-14

Commission Regulation (EU) No 1924/2006 of the European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods (OJ No. L 404, 30.12.2006, p. 10)

Hu H, Penn S, Lebrillo C, Brown PH. Isolation and characterization of soluble boron complexes in higher plants. Plant Physiol 1997; 113: 649-55. http://dx.doi.org/10.1104/pp.113.2.649

Stangoulis J, Tate M, Graham R, Bucknall M, Palmer L, Boughton B, Reid R. The mechanism of boron mobility in wheat and canola phloem. Plant Physiol 2010; 153(2): 876-81. http://dx.doi.org/10.1104/pp.110.155655

Lutz O, Humpfer E, Spraul M. Ascertainment of boric-acid esters in wine by 11B-NMR. Naturwissen 1991; 78: 67-69. http://dx.doi.org/10.1007/BF01206257

Pellerin P, Doco T, Vidal S, Williams P, Brillouet JM, O'Neill MA. Structural characterization of red wine rhamnogalacturonan II. Carbohydr Res 1996; 290(2): 183-97. http://dx.doi.org/10.1016/0008-6215(96)00139-5

O'Neill MA, Warrenfeltz D, Kates K, Pellerin P, Doco T, Darvill AG, Albersheim P. Rhamnogalacturonan-II, a pectic polysaccharide in the walls of growing plant cell, forms a dimer that is covalently cross-linked by a borate-ester. J Biol Chem 1996; 271: 22923-30. http://dx.doi.org/10.1074/jbc.271.37.22923

Matsunaga T, Nagata T. In vivo 11B-NMR observation of plant tissue. Anal Sci 1995; 11: 889-92. http://dx.doi.org/10.2116/analsci.11.889

Rotaru P, Scorei R, Harabor A, Dumitru MD. Thermal analysis of a calcium fructoborate sample. Thermochim Acta 2010; 506: 8-13. http://dx.doi.org/10.1016/j.tca.2010.04.006

Reyes-Izquierdo T, Nemzer B, Gonzalez AE, Zhou Q, Argumedo R, Shu C, Pietrzkowski ZB. Short-term intake of calcium fructoborate improves WOMAC and McGill scores and beneficially modulates biomarkers associated with knee osteoarthritis: a pilot clinical double-blinded placebo-controlled study. J Biomed Sci 2012; 4(2): 111-22.

Militaru C, Donoiu I, Craciun A, Scorei ID, Bulearca AM, Scorei RI. Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life. Nutrition 2013; 29(1): 178-83. http://dx.doi.org/10.1016/j.nut.2012.07.006

Nielsen FH. The saga of boron in food: from a banished food preservative to a beneficial nutrient for humans. Curr Topics Plant Biochem Physiol 1991; 10: 274-86.

Groziak MP. Boron therapeutics on the horizon. Am J Ther 2001; 8(5): 321-328. http://dx.doi.org/10.1097/00045391-200109000-00005

Travers RL, Rennie GC, Newnham RE. Boron and arthritis: The tesults of a double-blind pilot study. J Nutr Environ Med 1990; 1(2): 127-32. http://dx.doi.org/10.3109/13590849009003147

Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1). J Trace Elem Exp Med 2010; 24(4): 243-50. http://dx.doi.org/10.1016/j.jtemb.2010.03.003

Federal Institute for Risk Assessment (BfR) (Bundesinstitut für Risikobewertung) () Addition of boric acid or borax to food supplements. BfR Health Assessment 2006; 006. Available from: http://www.bfr.bund.de/cm/245/addition_of_boric_acid_ or_borax_to_food_supplements.pdf (9 November 2009)

Moore JA. An assessment of boric acid and borax using the IEHR Evaluative process for assessing human developmental and reproductive toxicity of agents. Reprod Toxicol 1997; 11(1): 123-60. http://dx.doi.org/10.1016/S0890-6238(96)00204-3

IoM (Institute of Medicine). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academies Press, Washington DC. 2000.

Dietary Supplement Health Education Act (DSHEA) of 1994. Public Law 103-417, available from FDA website: http://www.fda.gov.

Australian Register of Therapeutic Goods [homepage on the Internet]. Available from: http://www.tga.gov.au/index.htm; (Australian web site advertisements for authorized products cited in the Registry; personal communication from TGA to the NHPD, February 2007)

Price CJ, Strong PL, Marr MC, Myers CB, Murray FJ. Developmental toxicity NOAEL and postnatal recovery in rats fed boric acid during gestation. Fund Appl Toxicol 1996; 32: 179-93. http://dx.doi.org/10.1006/faat.1996.0121

IPCS (International Programme on Chemical Safety). Environmental Health Criteria 204: Boron. World Health Organization, Geneva, Switzerland 1998. Available from: http://www.inchem.org/documents/ehc/ehc/ehc204.htm

Health Canada. Boron as a Medicinal Ingredient in Oral Natural Health Products. 2007. Available from: http://www.hc-sc.gc.ca/dhp-mps/pubs/natur/boron-bore-eng.php

Naghii MR, Samman S. The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res 1997; 56: 273-86. http://dx.doi.org/10.1007/BF02785299

Bassil E, Hu H, Brown PH. Use of Phenylboronic Acids to Investigate Boron Function in Plants. Possible Role of Boron in Transvacuolar Cytoplasmic Strands and Cell-to-Wall Adhesion. Plant Physiol 2004; 136(2): 3383-5. http://dx.doi.org/10.1104/pp.104.040527

Bolaños L, Lukaszewski K, Bonilla I, Blevins D. Why boron? Plant Physiol Biochem 2004; 42: 907-12. http://dx.doi.org/10.1016/j.plaphy.2004.11.002