Factors Related to Body Mass Index in Women with Rheumatoid Arthritis – TOMORROW study

Authors

  • Yoshinari Matsumoto Department of Medical Nutrition, Osaka City University Graduate School of Human Life Science, 3-3-138 Sugimoto-cho, Sumiyoshi-ku, Osaka 558-8585, Japan
  • Yuko Sugioka enter for Senile Degenerative Disorders (CSDD), Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • Masahiro Tada Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • Tadashi Okano Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • Kenji Mamoto Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • Kentaro Inui Osaka City University Medical School
  • Daiki Habu Department of Rheumatosurgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
  • Tatsuya Koike Search Institute for Bone and Arthritis Disease (SINBAD), Shirahama Foundation for Health and Welfare, 1447 Shirahama-cho, Nishimuro-gun, Wakayama 649-2211, Japan

DOI:

https://doi.org/10.6000/1929-5634.2014.03.04.4

Keywords:

Rheumatoid arthritis, underweight, obesity, nutrition, cardiovascular disease, lifestyle.

Abstract

Objectives: This study aimed to clarify the relationship between body mass index (BMI) and patient characteristics, lifestyle factors, and cardiovascular disease (CVD)-related clinical data in women with rheumatoid arthritis (RA).

Methods: A total of 171 female outpatients with RA and 170 age-matched females without RA (controls) from the TOMORROW study (UMIN: 000003876) were included in this cross-sectional study. We divided subjects into 3 groups based on BMI: underweight (BMI < 18.5 kg/m2), normal weight (BMI ≥ 18.5 kg/m2 and < 25 kg/m2), and overweight (BMI ≥25 kg/m2), and compared RA disease activity, activities of daily living (ADL) assessed by modified health assessment questionnaire (mHAQ) score, energy and nutrient intake, and CVD risk-related clinical data.

Results: In patients with RA, mHAQ scores were lower in the normal weight group compared with the underweight and overweight groups (p < 0.05). Disease activity showed a similar trend. Energy, protein, and carbohydrate intake showed a positive correlation with BMI (p < 0.05). Blood pressure, C-reactive protein, uric acid, triglyceride, fasting plasma glucose, immune reactive insulin, HbA1c, and leptin showed a positive correlation with BMI, and adiponectin showed a negative correlation with BMI (p < 0.05). Control subjects showed similar trends.

Conclusions: BMI is related to ADL, disease activity, energy, protein and carbohydrate intake, and CVD risk-related clinical data, and might be an indicator of total health status in female patients with RA.

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Published

2014-12-22

How to Cite

Matsumoto, Y., Sugioka, Y., Tada, M., Okano, T., Mamoto, K., Inui, K., Habu, D., & Koike, T. (2014). Factors Related to Body Mass Index in Women with Rheumatoid Arthritis – TOMORROW study. Journal of Nutritional Therapeutics, 3(4), 168–174. https://doi.org/10.6000/1929-5634.2014.03.04.4

Issue

Vol. 3 No. 4 (2014)

Section

Articles

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