Anti-Inflammatory Activity of the Fruit Extract of Benincasa hispida
DOI:
https://doi.org/10.6000/1929-5634.2014.03.04.6Keywords:
Benincasa hispida, Phytochemicals, Anti-inflammatory, HRBC membrane stabilization, Carrageenan.Abstract
Benincasa hispida (Ash gourd, family: Cucurbitaceae) is well known for its medicinal property. In the Ayurvedic system, it is used as a rejuvenating agent and in the treatment of nervous disorders. Methanolic and petroleum fruit extracts was subjected to evaluation of phytochemicals and acute oral toxicity study. Further, Anti-inflammatory activity was performed using human red blood cell (HRBC) membrane stabilization assay and carrageenan induced paw edema in rat. Oral administration of methanolic extract of concentration (350 mg/kg) significantly reduced the paw edema (P < 0.05) in a dose dependent manner as compared to carrageenan induced rats.
References
Thaipong K, Boonprakob U, Crosby K, Cisneros-Zevallos L, Byrne DH. Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruits extracts. J Food Compos Anal 2006; 19: 669-675.
Volluri SS, Rao BS, Chippada SC, Vangalapati M. In-Vitro Anti-Arthritic Activity of Methanolic Extract of Bacopa Monnier. IJCEPR 2011; 2(2): 156-159.
Rabbani M, Sajjadi SE, Zarei HR. Anxiolytic effects of Stachys lavandulifolia Vahl on the elevated plus maze model of anxiety in mice. J Ethnopharmacology 2003; 89: 271-276. http://dx.doi.org/10.1016/j.jep.2003.09.008
Lewis DA. Anti-inflammatory drugs from plant and marine sources 1989; p. 135.
Goodwin JS, Brodwick M, Diet, Ageing and Cancer. Clin Geriatr Med 1995; 11: 577-589.
Grover JK, Adiga G, Vats V, Rathi SS. Extracts of Benincasa hispida prevent development of experimental ulcers. J Ethnopharmacol 2001; 78(2-3): 159-64. http://dx.doi.org/10.1016/S0378-8741(01)00334-8
Lee KH, Choi HR, Kim CH. Anti-angiogenic effect of the seed extract of Benincasa Cogniaux. J Ethnopharmacol 2005; 97(3): 509-13. http://dx.doi.org/10.1016/j.jep.2004.12.008
Kumar AD, Ramu P. Effects of methanolic extract of Benincasa hispida against histamine and acetylcoline induced bronchospam in guinea pigs. Indian J Pharmacol 2004; 34: 365-366.
Chandra BS, Umamageshwari S. Studies on anti-inflammatory activity of fruit rind extract of Benincasa hispida Cogn. India Drugs 2002; 39: 9-13.
Huang HY, Huang JJ, Tso TK, Tsai YC, Chang CK. Antioxidant and angiotensin- converting enzyme inhibition capacities of various parts of Benincasa hispida (wax gourd). Nahrng 2004; 48(3): 230-3. http://dx.doi.org/10.1002/food.200300428
Kumar A, Vimalavathini R. Possible anorectic effect of methanol extract of Benincasa hispida (Thunb) Cogn, fruit. Indian J Pharmacol 2004; 36: 348-350.
Dong MY, Lumz, Yin QH, Feng WM, Xu JX, Xu WM. Study of Benincasa hispida contents effective for protection of kidney. Jiangsu J Agric Sci 1995; 1: 46-55.
Pawlowska AM, Oleszek W, Braca A. Quali-quantitative analyses of flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits. J Agric Food Chem 2008; 56(9): 3377-3380. http://dx.doi.org/10.1021/jf703709r
Rosa MD, Giround JP, Willoghby DA. Studies of the acute inflammatory response induced in rats in different sites by Carrageenan and turpentine. J Pathol 1971; 104: 15-29. http://dx.doi.org/10.1002/path.1711040103
Harborne JB. Phytochemical methods guide to modern Technique of Plant Analysis, 3rd ed. Chapman and Hall, London 1998; 1: p. 135.
Shejawal N, Menon S, Shailajan S. A simple, sensitive and accurate method for rat paw volume measurement for rat paw volume measurement and its expediency in principle animal studies. Human Exper Toxicol 2013; 33(2): 123-129. http://dx.doi.org/10.1177/0960327113482594
Mohamed Saleem TK, Azeem AK, Dilip C, Sankar C, Prasanth NV, Duraisami R. Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees. Asian Pacific J Trop Biomed 1911; 147-149.
Rupasinghe VHP, Clegg S. Total antioxidant capacity, total phenolic content, mineral elements, and histamine concentrations in wines of different fruit sources. J Food Compos Anal 2007; 20: 133-137. http://dx.doi.org/10.1016/j.jfca.2006.06.008
Crunkhorn P, Meacock SCR. Mediators of the inflammation induced in the rat paw by carrageenan. Br J Pharmacol 1971; 42: 392. http://dx.doi.org/10.1111/j.1476-5381.1971.tb07124.x
Boughton-Smith NK, Deckin AM, Follenfant RL, Whittle BJ, Garland LG. Role of oxygen radicals and arachidonic acid metabolites in the reverse passive arthus reaction and carrageenan paw oedema in the rat. Br J Pharmacol 1993; 110: 896-902. http://dx.doi.org/10.1111/j.1476-5381.1993.tb13897.x
Di Rosa M. Biological properties of carrageenan. J Pharm Pharmacol 1972; 24: 89. http://dx.doi.org/10.1111/j.2042-7158.1972.tb08940.x
Downloads
Published
How to Cite
Issue
Section
License
Policy for Journals/Articles with Open Access
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work
Policy for Journals / Manuscript with Paid Access
Authors who publish with this journal agree to the following terms:
- Publisher retain copyright .
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .
