Nutraceuticals as Functional Foods
DOI:
https://doi.org/10.6000/1929-5634.2015.04.02.4Keywords:
Nutraceutical, Functional foods, Disease, Fortified foods, Health benefits.Abstract
Nutraceuticals are considered to be fortified or enriched foods providing all the essential nutrients required for maintaining the optimal health. A numerous studies have suggested the potential association of nutraceuticals with diet and health. This article gives a brief review on the classification of nutraceuticals on the basis of the availability of the nutraceutical from the natural sources which is further being processed and proving its medical health benefits in the market. The review also summarizes about the functional nutraceuticals acting as dietary supplements, suggested to have the capacity to significantly contribute to the modulation of the complex mechanisms of disease pathology with a view being that they may be essential in optimizing in vivo defences and help in maintaining wellness. Nonetheless, several more clinical and biological studies are needed to support guidelines for the intake of nutraceutical for the prevention and treatment in specific diseases and its medical benefits.
References
Aruoma OI. The impact of food regulation on the food supply chain. Toxicology 2006; 221: 119-127. http://dx.doi.org/10.1016/j.tox.2005.12.024
Gil Hardy. Nutraceuticals and functional foods: introduction and meaning. Nutrition 2000; 16 (7-8): 688-689. http://dx.doi.org/10.1016/S0899-9007(00)00332-4
Amin AR, Kucuk O, Khuri FR, et al. Perspectives for cancer prevention with natural compounds. J Clin Oncol 2009; 27: 2712-25. http://dx.doi.org/10.1200/JCO.2008.20.6235
US Congress. 100th Congress Orphan Drug Act Amendment, Part II; Federal Food Drug and Cosmetics Act, Washington, D.C. 1988; pp. 100-290;
Wyse R. Health economics and biotechnology drug development. J Biotech Healthcare 1997; 3: 363.
Whitman M. Understanding the perceived need for complementary and alternative nutraceuticals: lifestyle issues. Clin J Oncol Nurs 2001; 5: 190-194.
Kalra EK. Nutraceutical - Definition and introduction. AAPS Pharm Sci 2003; 5:1-2. http://dx.doi.org/10.1208/ps050325
Espín JC, García-Conesa MT, Tomás-Barberán FA. Nutraceuticals: facts and fiction. Phytochemistry 2007; 68: 2986-3008. http://dx.doi.org/10.1016/j.phytochem.2007.09.014
Singh J, Sinha S. Classification, Regulatory acts and applications of nutraceuticals for health. IJPBS 2012; 2(1): 177-187.
Pietro S, Matteo C, Maria M, Pietro AM, Maria LM, Salvatore N, et al. Nutraceuticals and dyslipidaemia: Beyond the common therapeutics. Journal of Functional Foods 2014; 6: 11-32. http://dx.doi.org/10.1016/j.jff.2013.12.006
Mendiola JA, Torres CF, Martín-Álvarez PJ, Santoyo S, Arredondo BO, Se˜norans FJ, et al. Use of supercritical CO2 to obtain extracts with antimicrobial activity from Chaetoceros muelleri microalga. A correlation with their lipidic content. Eur Food Res Technol 2007; 224: 505-510. http://dx.doi.org/10.1007/s00217-006-0353-6
Casado B, Affolter M, Kussmann M. OMICS-rooted studies of milk proteins, oligosaccharides and lipids. J Proteomics 2009; 73: 196-208. http://dx.doi.org/10.1016/j.jprot.2009.09.018
Vazquez L, Torres CF, Fornari T, et al. Recovery of squalene from vegetable oil sources using counter current supercritical carbon-dioxide extraction. J Supercrit Fluids 2007; 40: 59-66. http://dx.doi.org/10.1016/j.supflu.2006.04.012
Verardo V, Bendini A, Cerretani L, et al. Capillary gas chromatography analysis of lipid composition and evaluation of phenolic compounds by micellar electrokinetic chromatography in Italian walnut (Juglans Regia L.): irrigation and fertilization influence. J Food Quality 2009; 32: 262-281. http://dx.doi.org/10.1111/j.1745-4557.2009.00249.x
Lacomba R, Salcedo J, Alegria A, et al. Determination of sialic acid and gangliosides in biological samples and dairy products: a review. J Pharmaceut Biomed 2010; 51: 346-357. http://dx.doi.org/10.1016/j.jpba.2009.04.023
Dernovics M, Giusti P, Lobinski R. ICP-MS-assisted nano HPLC-electrospray Q/time-of-flight MS/MS selenopeptide mapping in Brazil nuts. J Anal At Spectrom. 2007; 22: 41-50. http://dx.doi.org/10.1039/B608041C
Beaulieu L, Thibodeau J, Bryl P, et al. Proteolytic processing of herring (Clupea harengus): biochemical and nutritional characterisation of hydrolysates. Int J Food Sci Technol 2009; 44: 2113- 2119. http://dx.doi.org/10.1111/j.1365-2621.2009.02046.x
Kim SJ, Kawaharada C, Suzuki T, Saito K, Hashimoto N, Takigawa S, et al. Effect of natural light periods on rutin, free amino acid and vitamin C contents in the sprouts of common (Fagopyrum esculentum Moench) and tartary (F. tataricum Gaertn.) buckwheats. Food Sci Technol Res 2006; 12: 199-205. http://dx.doi.org/10.3136/fstr.12.199
Guclu-Ustunda˘g O, Mazza G. Extraction of saponins and cyclopeptides from cow cockle seed with pressurized low polarity water. Food Sci Technol 2008; 41: 1600-1606.
Zanes Furlani RP, Teixeira GH. Vitamins B1, B2 contents in cultivated mushrooms. Food Chem 2008; 106: 816-819. http://dx.doi.org/10.1016/j.foodchem.2007.06.007
Anwar F, Przybylski R, Rudzinska M, et al. Fatty acid, tocopherol and sterol compositions of Canadian prairie fruit seed lipids. J Am Oil Chem Soc 2008; 85: 953-959. http://dx.doi.org/10.1007/s11746-008-1276-0
Bakowska-Barczak AM, Schieber A, Kolodziejczyk P. Characterization of Canadian black currant (Ribes nigrum L.) seed oils and residues. J Agric Food Chem 2009; 57: 11528-11536. http://dx.doi.org/10.1021/jf902161k
Kim WJ, Kim J, Veriansyah B, Kim JD, Lee YW, Oh SG, et al. Extraction of bioactive components from Centella asiatica using subcritical water. J Supercrit Fluid 2009; 48: 211-216. http://dx.doi.org/10.1016/j.supflu.2008.11.007
Naviglio D, Caruso T, Iannece P, et al. Characterization of high purity lycopene from tomato wastes using a new pressurized extraction approach. J Agric Food Chem 2008; 56: 6227-6231. http://dx.doi.org/10.1021/jf703788c
D’Antuono LF, Elementi S, Neri R. Glucosinolates in Diplotaxis and Eruca leaves: diversity, taxonomic relations and applied aspects. Phytochemistry 2008; 69: 187-199. http://dx.doi.org/10.1016/j.phytochem.2007.06.019
Brady K, Ho CT, Rosen RT, et al. Effects of processing on the nutraceutical profile of quinoa. Food Chem 2007; 100: 1209-1216. http://dx.doi.org/10.1016/j.foodchem.2005.12.001
Monta˜nes F, Olano A, Reglero G, et al. Supercritical technology as an alternative to fractionate prebiotic galacto-oligosaccharides. Sep Purif Technol 2009; 66: 383-389.
Li S, Lo CY, Ho CT. Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. J Agric Food Chem 2006; 54: 4176-4185. http://dx.doi.org/10.1021/jf060234n
Chatterjee S, Niaz Z, Gautam S, et al. Antioxidant activity of some phenolic constituents from green pepper (Piper nigrum L.) and fresh nutmeg mace (Myristica fragrans). Food Chem 2007; 101: 515-523. http://dx.doi.org/10.1016/j.foodchem.2006.02.008
Sharma UK, Sharma N, Gupta AP, et al. RP-HPTLC densitometric determination and validation of vanillin and related phenolic compounds in accelerated solvent extract of Vanilla plantifolia. J Sep Sci 2007; 30: 3174-3180. http://dx.doi.org/10.1002/jssc.200700229
Shadkami F, Estevez S, Helleur R. Analysis of catechins and condensed tannins by thermally assisted hydrolysis/methylation-GC/MS and by a novel two step methylation. J Anal Appl Pyrolysis 2009; 85: 54-65. http://dx.doi.org/10.1016/j.jaap.2008.09.001
Chi L, Li Z, Dong S, et al. Simultaneous determination of flavonoids and phenolic acids in Chinese herbal tea by beta-cyclodextrin based capillary zone electrophoresis. Microchimica Acta 2009; 167: 179-185. http://dx.doi.org/10.1007/s00604-009-0229-0
Chung JY, Choo JH, Lee MH, et al. Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine 2006; 13: 261-266. http://dx.doi.org/10.1016/j.phymed.2004.04.007
Gonzalez-Montelongo R, Lobo MG, Gonzalez M. Antioxidant activity in banana peel extracts: testing extraction conditions and related bioactive compounds. Food Chem 2010; 119: 1030-1039. http://dx.doi.org/10.1016/j.foodchem.2009.08.012
Chirinos R, Campos D, Betalleluz I, Giusti MM, Schwartz SJ, Tian Q, et al. High-performance liquid chromatography with photodiode array detection (HPLC-DAD)/HPLC-mass spectrometry (MS) profiling of anthocyanins from and ean mashua tubers (Tropaeolum tuberosum Ruiz and Pavon) and their contribution to the overall antioxidant activity. J Agric Food Chem 2006; 54: 7089-7097. http://dx.doi.org/10.1021/jf0614140
Green CE, Hibbert SL, Bailey-Shaw YA, et al. Extraction, processing and storage effects on curcuminoids and oleoresin yields from Curcuma longa L. grown in Jamaica. J. Agric Food Chem 2008; 56: 3664-3670. http://dx.doi.org/10.1021/jf073105v
Barbero GF, Liazid A, Palma M, et al. Ultrasound-assisted extraction of capsaicinoids from peppers. Talanta 2008; 75: 1332-1337. http://dx.doi.org/10.1016/j.talanta.2008.01.046
Sivakumar G, Aliboni A, Bacchetta L. HPLC screening of anti-cancer sulforaphane from important European Brassica species. Food Chem 2007; 104: 1761-1764. http://dx.doi.org/10.1016/j.foodchem.2006.11.040
Chairote EO, Chairote G, Niamsup H, et al. The presence and the content of Monacolins in Red Yeast rice prepared from Thai glutinous rice. World J Microbiol Biotechnol 2008; 24: 3039-3047. http://dx.doi.org/10.1007/s11274-008-9850-z
Kanu PJ, Zhu KR, Kanu JB, et al. Biologically active components and nutraceuticals in sesame and related products: a review and prospect. Trends Food Sci Tech 2007; 18: 599-608. http://dx.doi.org/10.1016/j.tifs.2007.06.002
Badimon L, Vilahur G, Padro T. Nutraceuticals and atherosclerosis, human trials. Cardiovasc Therap 2010; 28: 202-215. http://dx.doi.org/10.1111/j.1755-5922.2010.00189.x
Nair HB, Sung B, Yadav VR, et al. Delivery of anti-inflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochemical Pharmacology 2010; 80: 1833-1843. http://dx.doi.org/10.1016/j.bcp.2010.07.021
Zhou XJ, Hu XM, Yi YM, et al. Preparation and body distribution of freezedried powder of ursolic acid phospholipid nanoparticles. Drug Dev Ind Pharm 2009; 35: 305-10. http://dx.doi.org/10.1080/03639040802302165
Jalbert I. Diet, nutraceuticals and the tear film. Experimental Eye Research 2013; 117: 138-146. http://dx.doi.org/10.1016/j.exer.2013.08.016
Aruoma OI, Landes B, Ramful-Baboolall D, Bourdon E, Neergheen-Bhujun V, Wagner KH, et al. Functional benefits of citrus fruits in the management of diabetes. Prev Med 2012; 54: 12-16. http://dx.doi.org/10.1016/j.ypmed.2012.02.012
Bahadoran Z, Mirmiran P, Azizi F. Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. Journal of Diabetes & Metabolic Disorders 2013; 12: 43-52. http://dx.doi.org/10.1186/2251-6581-12-43
Kandaswami C, Middleton E. Free radical scavenging and antioxidant activity of plant flavonoids. In: D. Armstrong 2nd Eds. Free radicals in diagnostic medicine 1994; pp. 351-376 (New York: Plenum Press). http://dx.doi.org/10.1007/978-1-4615-1833-4_25
Wu CD, Wei GX. Tea as a functional food for oral health. Nutrition 2002; 18(5): 443-4. http://dx.doi.org/10.1016/S0899-9007(02)00763-3
Narotzki B, Reznick AZ, Aizenbud D, et al. Green tea: A promising natural product in oral health. Archives of Oral Biology 2012; 57: 429 - 435. http://dx.doi.org/10.1016/j.archoralbio.2011.11.017
Baici A. Analysis of glycosaminoglycans in human serum after oral administration of chondriotin sulphate. Rheumatol Int 1992; 12: 81-88. http://dx.doi.org/10.1007/BF00290259
Rajasekaran A, Sivagnanam G, Xavier R. Nutraceuticals as therapeutic agents: A Review. Research J Pharm and Tech 2008; 1(4): 328-340
Bhowmik D, Gopinath H, Pragati KB, et al. Nutraceutical -A Bright Scope and Opportunity of Indian Healthcare Market. The Pharma Innovation 2013; 1(11): 1-13.
Taylor Frederick R. Lifestyle changes, dietary restrictions, and nutraceuticals in migraine prevention. Techniques in Regional Anesthesia and Pain Management 2009; 13: 28-37. http://dx.doi.org/10.1053/j.trap.2009.03.008
Chaturvedi S, Sharma PK, Garg VK, et al. Role of Nutraceuticals in Health Promotion. International Journal of PharmTech Research 2011; 3 (1): 442-448.
Pandey M, Verma RK, Saraf SA. Nutraceuticals: New era of medicine and health. Asian J Pharm Clin Res 2010; 3: 11-15.
Sarin R, Sharma M, Singh R, et al. Nutraceuticals: A Review. International Research Journal of Pharmacy 2012; 3(4): 95-99.
Keservani Raj K, Vyas N, Jain S, et al. Nutraceutical and Functional Food as Future Food: A Review. Der Pharmacia Lettre 2010; 2(1): 106-116.
Downloads
Published
How to Cite
Issue
Section
License
Policy for Journals/Articles with Open Access
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work
Policy for Journals / Manuscript with Paid Access
Authors who publish with this journal agree to the following terms:
- Publisher retain copyright .
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .
