Green Tea Product Epigallocatechin Gallate (EGCG) Content and Label Information: A Descriptive Analysis

Authors

  • Marina V. Shkayeva Therapeutic Research Center (MS, PG), Creighton University Center for Drug Information & Evidence-Based Practice (PG, DH, JH, AR), University of Maryland School of Pharmacy, USA
  • Philip J. Gregory Therapeutic Research Center (MS, PG), Creighton University Center for Drug Information & Evidence-Based Practice (PG, DH, JH, AR), University of Maryland School of Pharmacy, USA
  • Matthew K. Pickering Therapeutic Research Center (MS, PG), Creighton University Center for Drug Information & Evidence-Based Practice (PG, DH, JH, AR), University of Maryland School of Pharmacy, USA
  • Darren J. Hein Therapeutic Research Center (MS, PG), Creighton University Center for Drug Information & Evidence-Based Practice (PG, DH, JH, AR), University of Maryland School of Pharmacy, USA
  • James Hu Therapeutic Research Center (MS, PG), Creighton University Center for Drug Information & Evidence-Based Practice (PG, DH, JH, AR), University of Maryland School of Pharmacy, USA
  • Aleah Rodriguez Therapeutic Research Center (MS, PG), Creighton University Center for Drug Information & Evidence-Based Practice (PG, DH, JH, AR), University of Maryland School of Pharmacy, USA

DOI:

https://doi.org/10.6000/1929-5634.2015.04.03.2

Keywords:

Nutraceutical, green tea, catechins, EGCG, supplement labeling

Abstract

Green tea’s popularity can be largely attributed to its potential health benefits, with an emphasis on antioxidant properties from its catechin constituents, especially (−)-epigallocatechin-3-gallate (EGCG). EGCG appears to be responsible for many of the potential health benefits of green tea. However, while higher intake levels may provide benefit, lower intake levels may not. The objective was to determine whether commercially available green tea products provide label information about EGCG content and other constituents and then to analyze the label information in terms of existing research. A descriptive analysis of product label information was conducted. In total, 105 green tea products evaluated, 58% of green tea supplements and 5% of green tea beverages included information about EGCG content on the label. Among the dietary supplement products providing sufficient information on the label, the amount of EGCG listed ranged from 70 mg to 600 mg per serving. The average EGCG per serving was 223.7 mg. The average reported caffeine content was 56.0 mg per serving. In conclusion, most green tea beverages to not provide adequate information about EGCG or other constituents. Green tea supplements are more likely to provide this information. One to two servings of green tea supplements are typically needed to achieve EGCG or catechin intake levels similar to those demonstrating efficacy in clinical studies. Consumers should consider selecting products that adequately describe constituent information on the label. Manufacturers should consider providing this essential information on the product label in order to better inform consumer decision-making.

Author Biography

James Hu, Therapeutic Research Center (MS, PG), Creighton University Center for Drug Information & Evidence-Based Practice (PG, DH, JH, AR), University of Maryland School of Pharmacy, USA

)

References

Rietveld A, Wiseman S. Antioxidant effects of tea: evidence from human clinical trials. J Nutr 2003; 133: 3275-84.

McKay DL, Blumberg JB. The role of tea in human health: An update. J Am Coll Nutr 2002; 21: 1-13. http://dx.doi.org/10.1080/07315724.2002.10719187

Riegsecker S, Wiczynski D, Kaplan MJ, Ahmed S. Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis. Life Sciences 2013; 93(8): 307-12. http://dx.doi.org/10.1016/j.lfs.2013.07.006

Zuo Y, Chen H, Deng Y. Simultaneous determination of catechins, caffeine and gallic acids in green, Oolong, black and pu-erh teas using HPLC with a photodiode array detector. Talanta 2002; 57(2): 307-16. http://dx.doi.org/10.1016/S0039-9140(02)00030-9

Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006; 66(2): 1234-40. http://dx.doi.org/10.1158/0008-5472.CAN-05-1145

Teausa [homepage on the Internet]. Tea Fact Sheet 2014. New York, NY: TeaUSA, Inc.; c2013 [cited 2013 March 1]. Available from: http://www.teausa.com/14655/tea-fact-sheet.

Clement Y. Can green tea do that? A literature review of the clinical evidence. Preventative Med 2009; 49(2-3): 83-87. http://dx.doi.org/10.1016/j.ypmed.2009.05.005

Kim A, Chiu A, Barone MK, Avino D, Wang F, Coleman CI,

et al. Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J Am Diet Assoc 2011; 111(11): 1720-9. http://dx.doi.org/10.1016/j.jada.2011.08.009

Liu K, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, et al. Effect of green tea on glucose control and insulin sensitivity: a

meta-analysis of 17 randomized controlled trials. Am J Clin Nutr 2013; 98(2): 340-8. http://dx.doi.org/10.3945/ajcn.112.052746

Tsao AS, Liu D, Martin J, Tang XM, Lee JJ, El-Naggar AK,

et al. Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Prev Res (Phila Pa) 2009; 2(11): 931-941. http://dx.doi.org/10.1158/1940-6207.CAPR-09-0121

Lambert J, Kennett MJ, Sang S, Reuhl KR, Ju J, Yang CS. Hepatotoxicity of high oral dose (−)-epigallocatechin-3-gallate in mice. Food Chem Toxicol 2010; 48(1): 409-16. http://dx.doi.org/10.1016/j.fct.2009.10.030

Wu K, Yao J, Boring D. Green tea extract-induced lethal toxicity in fasted but not in nonfasted dogs. Int J Toxicol 2011; 30(1): 19-20. http://dx.doi.org/10.1177/1091581810387445

Sarma DN, Barrett ML, Chavez ML, Gardiner P, Ko R, Mahady GB, et al. Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Saf 2008; 31(6): 469-84. http://dx.doi.org/10.2165/00002018-200831060-00003

Chow H, Cai Y, Hakim IA, Crowell JA, Shahi F, Brooks CA, et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res 2003; 9(9): 3312-9.

Ullmann U, Haller J, Decourt JP, Girault N, Girault J, Richard-Caudron AS, et al. A single ascending dose study of epigallocatechin gallate in healthy volunteers. J Int Med Res 2003; 31(2): 88-101. http://dx.doi.org/10.1177/147323000303100205

Fitz Simmons CR, Kidner N. Caffeine toxicity in a bodybuilder. J Accid Emerg Med 1998; 15(3): 196-197. http://dx.doi.org/10.1136/emj.15.3.196

Consumerlab [homepage on the Internet]. Product Review: Green Tea Supplements, Drinks, and Brewable Teas Review. c2015 [updated 2015 January 16; cited 2015 March 1]. Available from: https: //www.consumerlab.com/reviews/ Green_Tea_Review_Supplements_and_Bottled/Green_Tea/.

Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. Effects of caffeine on human health. Food Addit Contam 2003; 20(1): 1-30. http://dx.doi.org/10.1080/0265203021000007840

FDA to Investigate Added Caffeine. FDA For Consumers: Consumer Updates. c2013 [updated 2013 May 3; cited 2015 March 1]. Available from: http: //www.fda.gov/forconsumers/ consumerupdates/ucm350570.htm

Downloads

Published

2015-10-28

How to Cite

Shkayeva, M. V., Gregory, P. J., Pickering, M. K., Hein, D. J., Hu, J., & Rodriguez, A. (2015). Green Tea Product Epigallocatechin Gallate (EGCG) Content and Label Information: A Descriptive Analysis. Journal of Nutritional Therapeutics, 4(3), 81–84. https://doi.org/10.6000/1929-5634.2015.04.03.2

Issue

Section

Articles