The Effects of an Eight Week Weight Loss Program in Obese Adults Utilizing a Nutritional Supplement

Authors

  • Gerry Lane Metabolic and Genetic Research Institute, Largo, Florida, USA

DOI:

https://doi.org/10.6000/1929-5634.2015.04.04.1

Keywords:

Metabolic syndrome, insulin resistance, type II diabetes mellitus, obesity, atherosclerosis, hyperlipidemia

Abstract

A non-placebo controlled, blinded study utilizing a commercially available meal replacement (manufactured by Nutrition Laboratories Inc., Florida) studied 35 adult participants to determine the safety and efficacy of the product (a liquid nutrient concentrate) while measuring weight reduction, lipids, and adipose tissue, liver enzymes and metabolic indices (glucose, cholesterol and triglycerides) over an eight-week period. The average weight loss after 14 days was

18.2 (± 3.7) pounds and 28.4 (± 6.5) pounds at the conclusion of the eight-week trial. This was found to be statistically significant (p<.01). Patient’s metabolic functions were closely monitored in order to document therapeutic benefit, while monitoring for potential side effects. Total cholesterol was lowered in all participants (ave. reduction = 20.6 mg/dL) and every participant with clinically elevated cholesterol (≥ 200) at baseline, reported normal values after eight-weeks. Similarly, all participants with fasting hyperglycemia (s. glu. ≥ 100) returned to normal by the end of the study. This included three patients with NIDDM who were not well controlled prior to the study. There was no evidence of hypoglycemia (s. glu. ≤ 65). Participants with elevated liver enzymes at baseline reported normal SGOT & SGPT levels after two-weeks. No participant developed liver enzyme elevations. Subjective energy level of the participants was reported at baseline as low to average and reported as high to very high at the conclusion of the study. All participants lost total adipose tissue with the average change calculated at a 6.7% loss.

References

Prevalence of Obesity in the United States, Lawrence J. Appel, MD, MPH. JAMA 2014; 312(2): 188-189.

The economic impact of obesity in the United States; Ross A Hammond, Ruth Levine, Diabetes, metabolic syndrome and obesity: targets and therapy 2010; 3: 285-295.

http://obesitycoverage.com/honesty-and-divorce-after- bariatric-surgery

Phentermine hydrochloride capsules package insert (Fastin, SmithKline Beecham—US), Rev 3/98, Rec 7/98.

Mazindol product monograph (Sanorex, Novartis—Canada). In: Gillis MC, editor. CPS Compendium of pharmaceuticals and specialties. 33rd ed. Ottawa: Canadian Pharmacists Association 1998; pp. 1507-8.

Diethylpropion hydrochloride package insert (Tenuate and Tenuate Dospan, Merrell Pharmaceuticals—US), Rev 2/96, Rec 9/98.

Bostwick JM, Brown TM. A toxic reaction from combining fluoxetine and phentermine [letter]. J Clin Psychopharmacol 1996; 16(2): 189-90. http://dx.doi.org/10.1097/00004714-199604000-00012

Food and Drug Administration. FDA public health advisory: reports of valvular heart disease in patients receiving concomitant fenfluramine and phentermine 1997.

Cannistra LB, Davis SM, Bauman AG. Valvular heart disease associated with dexfenfluramine [letter]. N Engl J Med 1997; 337(9): 636. http://dx.doi.org/10.1056/NEJM199708283370912

Gatch, et al. Abuse Liability Profile of Three Substituted Tryptamines. Journal of Pharmacology and Experimental Therapeutics 2011; 338(1): 280-289. http://dx.doi.org/10.1124/jpet.111.179705

http://nulabinc.com/, Nulab, Inc., 2180 Calumet Street, Clearwater, FL 33765.

Tesoriere L, Butera D, Pintaudi AM, Allegra M, Livrea MA, Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C. Am J Clin Nutr 2004; 80(2): 391-5.

Uebelhack R, Busch R, Alt F, Beah ZH, Chong PW. Effects of cactus fiber on the excretion of dietary fat in healthy subjects: a double blind, randomized, placebo-controlled, crossover clinical investigation. Curr Ther Res Clin Exp 2014; 76: 39-44. http://dx.doi.org/10.1016/j.curtheres.2014.02.001

Grube B, Chong PW, Lau KZ, Orzechowski HD. A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study. Obesity (Silver Spring, MD), 2013; 21(1): 58-64. http://dx.doi.org/10.1002/oby.20244

Tanaka M, Misawa E, Habara N, Nomaguchi K, Yamada M, Toida T, Havasawa H, Takase M, Inagake M, Higuchi R. Identification of five phytosterols from Aloe vera gel as anti- diabetic compounds. Biol Pharm Bull 2006; 29(7): 1418-22. http://dx.doi.org/10.1248/bpb.29.1418

Okuyr A, Can A, Akev N, Baktir G, Sutlupinar N. Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models. Phytother Res 2001; 15(2): 157-61. http://dx.doi.org/10.1002/ptr.719

Derosa G, Romano D, D’Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol(®)) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: A randomized, placebo-controlled, clinical trial. Phytomedicine 2015; 22(2): 231-7. http://dx.doi.org/10.1016/j.phymed.2014.11.018

Załuski D, Janeczko Z. Variation in phytochemicals and bioactivity of the fruits of Eleutherococcus species cultivated in Poland. Nat Prod Res 2015; 1-5.

Bleakney TL. Deconstructing an adaptogen: Eleutherococcus senticosus. Holist Nurs Pract 2008; 22(4): 220-4. http://dx.doi.org/10.1097/01.HNP.0000326005.65310.7c

Seon-Hee OH, Byung-Hoon L. A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicology and Applied Pharmacology 2004; 194(3): 221-229.

Mota MA, Landim JS, Targino TS, Silva SF, Silva SL, Pereira MR. Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice. Acta Cir Bras 2015; 30(4): 242-246. http://dx.doi.org/10.1590/S0102-865020150040000002

Zhong Xi Yi Jie He Xue BaoChen QG, Zeng YS, Tang JY, Qin YJ, Chen SJ, Zhong ZQ. Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress 2008; 6(9): 952-5.

Pan SY, Dong H, Zhao XY, Xiang CJ, Fang HY, Fong WF, Yu ZL, Ko KM. Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice. J Pharm Pharmacol 2008; 60(3): 399-403. http://dx.doi.org/10.1211/jpp.60.3.0017

Mendes FR, Carlini EA. Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in Brazil. J Ethnopharmacol 2007; 109(3): 493-500. http://dx.doi.org/10.1016/j.jep.2006.08.024

Yoon YI, Chung M, Hwang JS, Han MS, Goo TW, Yun EY. Allomyrina dichotoma (Arthropoda: Insecta) larvae confer resistance to obesity in mice fed a high-fat diet. Nutrients 2015; 7(3): 1978-91. http://dx.doi.org/10.3390/nu7031978

Lee MH, Choi HM, Hahm DH, Her E, Yang HI, Yoo MC, Kim KS. Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae. Mol Med Rep 2012; 6(4): 791-6. http://dx.doi.org/10.3892/mmr.2012.989

Chong PW, Beah ZM, Grube B, Riede L. IQP-GC-101 reduces body weight and body fat mass: a randomized, double-blind, placebo-controlled study. Phytother Res 2014; 28(10): 1520-6. http://dx.doi.org/10.1002/ptr.5158

Astell KJ, Mathai ML, Su XQ. Plant extracts with appetite suppressing properties for body weight control: a systematic review of double blind randomized controlled clinical trials. Complement Ther Med 2013; 21(4): 407-16. http://dx.doi.org/10.1016/j.ctim.2013.05.007

Picon PD, Picon RV, Costa AF, Sander GB, Amaral KM, Aboy AL, Henriques AT. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. BMC Complement Altern Med 2010; 10: 17. http://dx.doi.org/10.1186/1472-6882-10-17

Astell KJ, Mathai ML, Su XQ. Plant extracts with appetite suppressing properties for body weight control: a systematic review of double blind randomized controlled clinical trials. Complement Ther Med 2013; 21(4): 407-16. http://dx.doi.org/10.1016/j.ctim.2013.05.007

Tayarani-Najaran Z, Talasaz-Firoozi E, Nasiri R, Jalali N, Hassanzadeh M. Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy- induced nausea and vomiting. Ecancermedicalscience 2013; 7: 290.

Leonard SS, Keil D, Mehlman T, Proper S, Shi X, Harris GK. Essiac tea: scavenging of reactive oxygen species and effects on DNA damage. J Ethnopharmacol 2006; 103(2): 288-96. http://dx.doi.org/10.1016/j.jep.2005.09.013

Kang JJ, Samad MA, Kim KS, Bae S. Comparative anti- inflammatory effects of anti-arthritic herbal medicines and ibuprofen. Nat Prod Commun 2014; 9(9): 1351-6.

Downloads

Published

2016-02-02

How to Cite

Lane, G. (2016). The Effects of an Eight Week Weight Loss Program in Obese Adults Utilizing a Nutritional Supplement. Journal of Nutritional Therapeutics, 4(4), 115–118. https://doi.org/10.6000/1929-5634.2015.04.04.1

Issue

Section

Special Issue - The Role of Neutraceuticals in the Prevention & Treatment of Metabolic Syndrome