Selective Plant Extracts and their Combination as the Nutritional Therapeutic Remedies
DOI:
https://doi.org/10.6000/1929-5634.2016.05.01.1Keywords:
General adaptation syndrome, Chronic stress consequences, Adaptogenic plant extracts, Nutritional supplement “AdMaxâ€, Chronic fatigue, Energy metabolismAbstract
The article is a survey of some plant extracts that possess ability to restore metabolic disturbances evoked by chronic stress. Chronic stress triggers a number of common illnesses, including depression, chronic physical and mental fatigue, neuroses, cardiovascular diseases, ulceration of stomach and intestine, diabetes mellitus, obesity and alcohol abuse. One of the early consequences of chronic stress is the decrease of functional activity of immune system that reduces resistance against infections, allergies, asthma, autoimmune disorders, rheumatoid arthritis. The initial stages of chronic stress consequences are suppression of immune system, disturbances of hormonal balance, hydrocarbon, lipid, and energy metabolism. Applicability of the extracts from Leuzea carthamoides, Rhodiola rosea, Eleutherococcus senticosus, Schizandra chinensis and their combination “AdMax” to counteract the initial stages of chronic stress consequences is considered.
References
Chrousos GP. Stressors, stress, and neuroendocrine integration of the adaptive response. Ann NY Acad Sci 1998; 851: 311-35. http://dx.doi.org/10.1111/j.1749-6632.1998.tb09006.x
Chrousos GP, Gold PW. The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis. JAMA 1992; 267: 1244-52. http://dx.doi.org/10.1001/jama.1992.03480090092034
Selye H. The general adaptation syndrome and the diseases of adaptation. J Clin Endocrinol 1946; 6: 117-30. http://dx.doi.org/10.1210/jcem-6-2-117
Panossian A, Wikman G. Evidence-bases efficacy adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 2009; 4: 198-219. http://dx.doi.org/10.2174/157488409789375311
Lafont R, Dinan L. Practical uses for ecdysteroids in mammals including humans: an update. J Insect Sci 2003; 3: 7-35. http://dx.doi.org/10.1673/031.003.0701
Gilbert B, Alves LF. Synergy in plant medicines. Curr Med Chem 2003; 10: 13-20. http://dx.doi.org/10.2174/0929867033368583
Yang Y, Zhang Z, Li S, et al. Synergy effects of herb extracts: pharmacokinetics and pharmacodynamics basis. Fitoterapia 2014; 92 : 133-47. http://dx.doi.org/10.1016/j.fitote.2013.10.010
Syrov VN, Kurmukov AG. Anabolic activity of phytoecdysone – ecdysterone isolated from Rhaponticum carthamoides (Will.) Iljin. Farmacol Toksikol 1967; 39: 690-3.
Kokoska L, Janovska D. Chemistry and pharmacology of Rhaponticum carthamoides: a review. Phytochemistry 2009; 70: 842-55. http://dx.doi.org/10.1016/j.phytochem.2009.04.008
Saratikov AS, Tusov SF. Influence of Leuzea carhtamoides on physical performance and some functional tests of the organism. Isv SO AN SSSR, Ser Biol. 1963; 12: 126-32.
Gadzhieva RM, Portugalov SN, Paniushkin VV, et al. Comparative study of anabolic activity of substances of plant origin: Ecdisten, Leveton, and Prime plus. Eksp Klin Farmakol 1995; 58: 46-8.
Azizov AP, Seifulla RD, Chubarova AV. Effect of tincture of leuzea and leveton on humoral immunity of athletes. Eksp Klin Farmakol 1997; 60: 47-8.
Novikov VS, Shamarin IA, Bortnovskii VN. A trial of the pharmacological correction of sleep disorders in sailors during a sea voyage. Voen Med Zh 1992; (8): 47-9.
Marina TF. Influence of CNS stimulators of plant origin on reflex activity of spinal cord. In: Stimulators of the Central Nervous System. 1966, Tomsk, p. 31-6.
Mirzaev YuR. Study of the effects of Ecdysten on the sexual function indices under experimental and clinical conditions. Eksp Klin Farmakol 2000; 63: 35-7.
Syrov VN, Khushbaktova ZA, Komarin AS, et al. Experimental and clinical evaluation of the efficacy of ecdysten in the treatment of hepatitis. Eksp Klin Farmakol. 2004; 67: 56-9.
Mosharrof AH. Effects of extract from Rhaponticum carthamoides (Willd) Iljin (Leuzea) on learning and memory in rats. Acta Physiol Pharmacol Bulg 1987; 13: 37-42.
Opletal L, Sovova M, Dittrich M, et al. Phytotherapeutic aspects of diseases of the circulatory system. Leuzea carthamoides (WILLD.) DC: the status of research and possible use of the taxon. Ceska Slov Farm 1997; 46: 247-55.
Horn DH, Fabbri S, Hampshire F, et al. Isolation of crustecdysone (20R-hydroxyecdysone) from a crayfish (Jasus lalandei H. Milne-Edwards). Biochem J 1968; 109: 399-406. http://dx.doi.org/10.1042/bj1090399
Chermnykh NS, Simonovskii VL, Shutko GV, et al. The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles. Farmacol Toksikol 1988; 51: 57-60.
Kholodova IuD, Tugai VA, Zimina VP. Effect of vitamin D3 and 20-hydroxyecdysone on the content of ATP, creatine phosphate, carnosine and Ca2+ in skeletal muscles. Ukr Biokhim Zh 1997; 69: 3-9.
Syrov VN, Nasyrova SS, Khushbaktova ZA. The results of experimental study of phytoecdysteroids as erythropoiesis stimulators in laboratory animals. Eksp Klin Farakol 1997; 60: 41-4.
Yoshida T, Otaka T, Uchiyama M, et al. Effect of ecdysterone on hyperglycemia in experimental animals. Biochem Pharmacol 1971; 20: 3263-8. http://dx.doi.org/10.1016/0006-2952(71)90431-X
Lupien PJ, Hinse C, Chaudhary KD. Ecdysterone as a hypoholesterolemic agent. Arch Int Physiol Biochim 1969; 77: 206-12. http://dx.doi.org/10.3109/13813456909109700
Catalan RE, Aragones MD, Godoy JE, et al. Alterations in rat lipid metabolism following ecdysterone treatment. Comp Biochem Physiol 1985; 81b: 771-5. http://dx.doi.org/10.1016/0305-0491(85)90403-1
Matsuda H, et al. Effect of ecdysterone on experimental atherosclerosis in rabbits. Nippon Yakurigaku Zasshi 1974; 70: 325-39. [Japanese] http://dx.doi.org/10.1254/fpj.70.325
Catalan RE, Aragones MD, Godoy JE, et al. Ecdysterone induces acetylcholinesterase in mammalian brain. Comp Biochem Physiol 1984; 78c: 193-5. http://dx.doi.org/10.1016/0742-8413(84)90068-9
Chaudhary KD, Lupien PJ, Hinse C. Effect of ecdysone on glutamic decarboxylase in rat brain. Experientia 1969; 25: 250-51. http://dx.doi.org/10.1007/BF02034373
Chiang HC, Wang JJ, Wu RT. Immunomodulating effects of the hydrolysis products of formosamin C and β-ecdysone from Paris formosana Hayata. Anticancer Res 1992; 12: 1475-8.
Oyhar A, Strangmann-Diekmann M, Kiltz HH, et al. Characterization of a specific ecdysteroid receptor-DNA complex reveals common properties for invertebrate and vertebrate hormone-receptor/DNA interaction. Eur J Biochem 1991; 200: 329-35. http://dx.doi.org/10.1111/j.1432-1033.1991.tb16189.x
Brinkman AO. Steroid hormone receptors: activators of gene transcription. J Pediatr Endocrinol 1994; 7: 275-82. http://dx.doi.org/10.1515/JPEM.1994.7.4.275
Nair KS. Aging muscle. Am J Clinical Nutrition 2005; 81: 953-63.
Balagopal P, Schimke JC, Ades P, et al. Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise. Am J Physiol Endocrinol Metab 2001; 280: E203-8.
Short KR, Bigelow ML, Kahl J, et al. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA 2005; 102: 5618-23. http://dx.doi.org/10.1073/pnas.0501559102
Radyuk SN, Klichko VI, Orr WC. Catalase expression in Drosophila melanogaster is responsive to ecdysone and exhibits both transcriptional and post-transcriptional regulation. Arch Insect Biochem Physiol 2000; 45: 79-93. http://dx.doi.org/10.1002/1520-6327(200010)45:2<79::AID-ARCH4>3.0.CO;2-Y
Budesinsky M, Vokac K, Harmatha J, et al. Additional minor ecdysteroid components of Leuzea carthamoides. Steroids 2008; 73: 502-14. http://dx.doi.org/10.1016/j.steroids.2007.12.021
Hajdu Z, Varga E, Hohmann J, et al. A stilbene from the roots of leuzea carthamoides. J Nat Prod 1998; 61: 1298-9. http://dx.doi.org/10.1021/np980128i
Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; Nov 1, Epub 05354: 1-6.
Kuiper GG, Faber PW, van Rooij HC, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998; 139: 4252-63.
Syrov VN. Phytoecdysteroids: their biological effects in the body of higher animals and the outlook for their use in medicine. Eksp Klin Farmakol 1994; 57: 61-6. [Russian]
Tolonen A, Pakonen M, Hohtola A, et al. Phenylpropanoid glycosides from Rhodiola rosea. Chem Pharm Bull (Tokio) 2003; 51: 476-70. http://dx.doi.org/10.1248/cpb.51.467
Saratikov AS. Golden Root. Goldberg ED editor, Tomsk University publishing house. Tomsk. 1974.
Wang Q, Wang J, Sun LJ, et al. Salidroside protects the hypothalamic-pituitary-gonad axis on male rats undergoing negative psychological stress in experimental navigation and intensive exercise. Zhonghua Nan Ke Xue 2009; 15: 331-6.
Yu S, Liu M, Gu X, et al. Neuroprotective effects of salidroside in the PC12 сell model exposed to hypoglycemia and serum limitation. Cell Mol Neurobiol 2008; 28: 1067-78. http://dx.doi.org/10.1007/s10571-008-9284-z
Wu T, Zhou H, Lin Z, et al. Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. Eur J Pharmacol 2009; 613: 93-9. http://dx.doi.org/10.1016/j.ejphar.2009.04.012
Li HB, Ge YK, Zheng XX, et al. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol 2008; 588: 165-9. http://dx.doi.org/10.1016/j.ejphar.2008.04.036
Abidov M, Crendal F, Grachev S, et al. Effects of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med. 2003; 136: 585-7. http://dx.doi.org/10.1023/B:BEBM.0000020211.24779.15
Lee FT, Kuo TY, Liou SY, et al. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am J Chin Med 2009; 37: 557-72. http://dx.doi.org/10.1142/S0192415X09007053
De Bock K, Eijnde BO, Ramackers, et al. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004; 14: 298-307.
Udintsev SN, Schakhov VP. Decrease of cyclophosphamide heamatotoxicity by Rhodiola rosea root extract in mice with Ehrlich and Lewis transplantable tumors. Eur J Cancer 1991; 27: 1182. http://dx.doi.org/10.1016/0277-5379(91)90323-6
Kaliko IM, Tarasova AA. Effect of Leuzea and Golden root extracts on dynamic specificity of the central nervous system function. In: Stimulators of the Central Nervous System. p. 115-20. Tomsk University publishing house, 1966, Tomsk.
Spasov AA, Wikman GK, Mandrikov VB, et al. A duble-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 2000; 7: 85-9. http://dx.doi.org/10.1016/S0944-7113(00)80078-1
Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003; 10: 95-105. http://dx.doi.org/10.1078/094471103321659780
Olsson EM, von Scheele B, Pannosian AG, et al. A randomized, double-blind, placebo-controlled, parallel-group study of the standardized extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med 2009; 75: 105-12. http://dx.doi.org/10.1055/s-0028-1088346
Stancheva SL, Mosharrof A. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monoamines. Med Physiol 1987; 40: 85-7.
Chen OG, Zeng YS, Qu ZQ, et al. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine 2009; 16: 830-8. http://dx.doi.org/10.1016/j.phymed.2009.03.011
Brekhman II, Kirillov OI. Effect of Eleutherococcus on alarm-phase of stress. Life Sci 1969; 8: 113-21. http://dx.doi.org/10.1016/0024-3205(69)90083-6
Hikino H, Takahashi M, Otake K, et al. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986; 49: 293-7. http://dx.doi.org/10.1021/np50044a015
Steinmann GG, Esperester A, Joller P. Immunopharmacological in vitro effects of Eleutherococcus senticosus extract. Arzneimittelforschung 2001; 51: 76-83.
Mowrey DB. Siberian ginseng, eleuthero root. In: Herbal Tonic Therapies. Keats Publishing, Inc., 1993. New Canaan, Conn. p. 192-9.
Bleakney TL. Deconstructing an adaptogen: Eleutherococcus senticosus. Holist Nurs Pract 2008; 22: 220-4. http://dx.doi.org/10.1097/01.HNP.0000326005.65310.7c
Drozd J, Sawicka T, Prosinska J. Estimation of humoral activity of Eleitherococcus senticosus. Acta Pol Pharm 2002; 59: 395-401.
Bohn B, Nebe CT, Birr C. Flow-cytometric studies with eleutherococcus senticosus extract as immunomodulatory agent. Arzneimittelforschung 1987; 37: 1193-6.
Schmolz MW, Sacher F, Aicher B. The synthesis of Rantes, G-CSF, IL-4, IL-5, IL-6, IL12 and IL-13 in human whole-blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots. Phytother Res 2001; 15: 268-70. http://dx.doi.org/10.1002/ptr.746
Walker M. Adaptogens: nature’s answer to stress. Townsend Lett Doctors 1994; July: 751-5.
Asano K, Takahashi T, Miyashita M, et al. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med 1986; 48: 175-7. http://dx.doi.org/10.1055/s-2007-969114
McNaughton L, Egan G, Caelli G. A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness. Int Clin Nutr Rev 1989; 90: 32-5.
Szolomivki J, Samochowiec L, Wojcicki J, et al. The influence of active components of Eleutherococcus senticosus on cellular defense and physical fitness in man. Phytother Res 2000; 14: 30-5. http://dx.doi.org/10.1002/(SICI)1099-1573(200002)14:1<30::AID-PTR543>3.0.CO;2-V
Kimura Y, Sumiyoshi M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming mice. J Ethnopharmacol 2004; 95: 447-53. http://dx.doi.org/10.1016/j.jep.2004.08.027
Chen Z, Yin CP, Liu JH, et al. Extract of acanthopanacis senticosus improves sperm motility of asthenospermia patients in vitro. Zhonghua Nan Ke Xue 2007; 13: 21-3. [Chinese]
Niu HS, Liu HS, Liu EM, et al. Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats. Planta Med 2008; 74: 109-13. http://dx.doi.org/10.1055/s-2008-1034275
Wiegant FA, Surinova S, Ytsma E, et al. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 2009; 10: 27-42. http://dx.doi.org/10.1007/s10522-008-9151-9
Tohda C, Ichimura M, Bai Y, et al. Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss. J Pharmacol Sci 2008; 107: 329-39. http://dx.doi.org/10.1254/jphs.08046FP
Cicero AF, Derosa G, Brilliante R, et al. Effect of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr Suppl 2004; (9): 69-73. http://dx.doi.org/10.1016/j.archger.2004.04.012
Panossian A, Wikman G. Pharmacology of Schizandra chinensis Bail.: an overview of Russian research and uses in medicine. J Ethnopharmacol 2008; 118: 183-212. http://dx.doi.org/10.1016/j.jep.2008.04.020
Lebedev AA. Limonnik. Tashkent, 1971. [Russian]
Kochetkov NK, Khorlin A, Chizhov OS. 1961. Schizandrin - lignan of unusual structure. Tetrahedron Lett 1961; 730-4. http://dx.doi.org/10.1016/S0040-4039(01)91684-3
Kochetkov NK, Budovsky EI, Shibaev VN, et al. 1962. Deoxyschizandrin - structure and total synthesis. Tetrahedron Lett 1962; 361-6. http://dx.doi.org/10.1016/S0040-4039(00)70882-3
Ikeya Y, Taguchi H, Yosioka I, et al. The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. Chem Pharm Bull 1979 (Tokio); 27: 1383- 94.
Li X. Scavenging effects on active oxygen radicals by schizandrins with different structures and configurations. Free Radic Biol Med 1990; 9: 99-104. http://dx.doi.org/10.1016/0891-5849(90)90111-U
Zhao BL, Jiang W, Zhao Y, et al. Scavenging effect of schizandrins on active oxygen radicals. Cell Biol Int Rep 1990; 14: 99-109. http://dx.doi.org/10.1016/0309-1651(90)90027-V
Choi YW, Takamatsu S, Khan SI, et al. Schisandrene, a bibenzocyclooctadiene lignan from Schizandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J Nat Prod 2006; 69: 356-9. http://dx.doi.org/10.1021/np0503707
Jung CH, Hong MH, Kim JH, et al. Protective effect of phenolic-rich fraction from Schizandra chinensis against H(2)O(2)-induced apoptosis in SH-SY5Y cells. J Pharm Pharmacol 2007; 59: 455-62. http://dx.doi.org/10.1211/jpp.59.3.0016
Ip SP, Che CT, Ko KM. Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice. Chung Kuo Yao Li Hsueh Pao 1998; 19: 313-6.
Kubo S, Dankwarth G, Puschel K. Effect of gomisin A (TJN-101) on liver regeneration. Planta Med 1992; 58: 489-92. http://dx.doi.org/10.1055/s-2006-961532
Guo LY, Hung TM, Bae KH, et al. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol 2008; 591: 293-9. http://dx.doi.org/10.1016/j.ejphar.2008.06.074
Chiu PY, Ko KM. Shizandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats. Mol Cell Biochem 2004; 266: 139-44. http://dx.doi.org/10.1023/B:MCBI.0000049151.79238.30
Chen N, Chin PY, Ko KM, et al. Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats. Bio Pharm Bull 2008; 31: 1387-91. http://dx.doi.org/10.1248/bpb.31.1387
Pan SY, Dong H, Zhao XY, et al. Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice. J Pharm Pharmacol 2008; 60: 399-403. http://dx.doi.org/10.1211/jpp.60.3.0017
Lee IS. Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists. Biol Pharm Bull 1999; 22: 265-7. http://dx.doi.org/10.1248/bpb.22.265
Kormosh N, Laktionov K, Antoshechkina M. Effect of a combination of extract from several plants on cell-mediated and humoral immunity of patients with advanced ovarian cancer. Phytother Res 2006; 20: 424-5. http://dx.doi.org/10.1002/ptr.1889
Lane G. A double-blind, placebo-controlled trial, evaluating the effect of a proprietary blend of plant adaptogens on sexual satisfaction and sexual response in adult males. J Nutr Ther 2014; 3: 142-58. http://dx.doi.org/10.6000/1929-5634.2014.03.03.5
Rosen RC, Riley A, Wagner G, et al. The international index of erectile function (IIEF): a multidimentional scale for assessment of erectile dysfunction. Urology 1997; 49(6): 822-30. http://dx.doi.org/10.1016/S0090-4295(97)00238-0
Antoshechkin A, Olalde J, Antoshechkina M, et al. Influence of the plant extract complex “AdMax” on global gene expression levels in cultured human fibroblasts. J Diet Suppl 2008; 5: 293-304. http://dx.doi.org/10.1080/19390210802414337
Robishaw JD, Neely JR. Pantothenate kinase and control of CoA synthesis in heart. Am J Physiol 1984; 246 (4 Pt 2): H532-41.
Robishaw JD, Neely JR. Coenzyme A metabolism. Am J Physiol 1985; 248 (1 Pt 1): E1-9.
Westaway SK, Chang KH, Levinson B, et al. Gene symbol: PANK2. Disease: pantothenate kinase-associated neurodegeneration (PKAN). Hum Genet 2006; 119: 671-2.
Tretter L, Sipos I, Adam-Vizi V. Initiation of neuronal damage by complex I deficiency and oxidative stress in Parkinson’s disease. Neurochem Res 2004; 29: 569-77. http://dx.doi.org/10.1023/B:NERE.0000014827.94562.4b
Atamna H, Frey WH. Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer’s disease. Mitochondrion 2007; 7: 297-310. http://dx.doi.org/10.1016/j.mito.2007.06.001
Mattson MP, Pedersen WA, Duan W, et al. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer’s and Parkinson’s diseases. Ann NY Acad Sci 1999; 893: 154-75. http://dx.doi.org/10.1111/j.1749-6632.1999.tb07824.x
Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995; 38: 357-66. http://dx.doi.org/10.1002/ana.410380304
Alikhani N, Ankarcrona M, Glaser E, et al. Mitochondria and Alzheimed’s disease: amyloid-beta peptide uptake and
degradation by the presequence protease, hPreP. J Bioenerg Biomembr 2009; 41(5): 447-51. http://dx.doi.org/10.1007/s10863-009-9244-4
Su B, Wang X, Bonda D, et al. Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta 2010; 1802(1): 135-42. http://dx.doi.org/10.1016/j.bbadis.2009.09.013
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