Synthesis and Characterization of N-Substituted Tetrahydroiso-quinoline Derivatives via a Pictet-Spengler Condensation
Pages 169-174
Heta A. Patel and Arun L. Patel

DOI: http://dx.doi.org/10.6000/1929-5030.2014.03.03.5

Published: 18 September 2014

Abstract: Synthesis of N-substituted 1,2,3,4 –tetrahydroisoquinoline derivatives and bis-isoquinoline has been carried out via a Pictet-Spengler condensation. Tetrahydroisoquinolines were obtained from 2-(3’,4’-dimethoxyphenyl) ethylamine in four steps. The entire synthesized compounds were characterized by IR, ¹H NMR and mass spectral data.