Solubilization of Hydroxypropyl-β-Cyclodextrin on Cholesterol in Aqueous Solution
Pages 48-52
Changjun Zou, Lu Zhou, Yali Wang and Lu Li

DOI: http://dx.doi.org/10.6000/1929-5030.2014.03.02.1

Published: 30 May 2014

Abstract: Hydroxypropyl-β-Cyclodextrin (HP-β-CD), prepared via reaction of β-Cyclodextrin (β-CD) and propylene oxide (PO), is utilized to research solubilization of HP-β-CD on cholesterol in aqueous solution. HP-β-CD is characterized by Fourier Transform Infrared Spectrometry (FT-IR), and concentrations of cholesterol solution are measured by ultraviolet and visible (UV VIS) spectrophotometer. The research on optimal synthesis conditions of HP-β-CD indicates that sodium hydroxide amounts have the most effect on yields of product. The maximum solubilization multiples of HP-β-CD reaches 15, below which molecular rate of HP-β-CD and cholesterol in inclusion complex is 1:1.