Lifescience Global

Editor’s Choice : Comparison of Post Hoc Multiple Pairwise Testing Procedures as Applied to Small k-Group Logrank Tests

ijsmr logo-pdf 1349088093

Comparison of Post Hoc Multiple Pairwise Testing Procedures as Applied to Small k-Group Logrank Tests
Pages 104-116
Moonseong Heo and Andrew C. Leon
DOI:
http://dx.doi.org/10.6000/1929-6029.2013.02.02.04
Published: 30 April 2013


Abstract: The logrank test is widely used to compare groups on distribution of survival time in the presence of censoring. There is no convention for post hoc pairwise comparisons after a significant omnibus k-group logrank test. This simulation study compares four post hoc pairwise testing procedures: Bonferroni, Dunn-Šidák,Hochberg, and unadjusted post hoc logrank test procedure. Evaluation criteria include, familywise type I error rate, correct decision rate, number of correctly rejected pairs, and false discovery rate. We demonstrated that when conditioned upon rejection of the omnibus test, multiplicity adjustments may be unnecessary and can be overly conservative when k is at most 4, or number of comparisons is no greater than 6. This is supported by the results that the performance of the unadjusted post hoclogrank test procedure is preferred over the others on all criteria except for the false discovery rate. The Hochberg procedure appears to be superior among the adjustments examined. Data from a clinical trial for suicide prevention illustrate these approaches where number of comparison groups is often limited.

Keywords: Logrank test, multiplicity adjustment, post hoc tests, survival analysis.
Download Full Article
Submit to FacebookSubmit to Google PlusSubmit to TwitterSubmit to LinkedIn

OUR STRENGTHS

♦  Worldwide readership
♦  High quality content
♦  Maximum visibility
♦  Efficient publishing
♦  Optional Open Access

Publish your Research

Survey

As an author what type of publishing model you prefer?

780
Open Access
493
Optional Open Access
338
Subscription based
5 Votes left