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Editor’s Choice : The Effects of Consumption L-Arabinose on Metabolic Syndrome in Humans

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The Effects of Consumption L-Arabinose on Metabolic Syndrome in Humans
Pages 116-126
Ziming Yang, Dianpeng Li, Haiying Jiang, Guiyun Qian, Weiguo Sui, Guimian Zou and Hourui Zhang
DOI:
http://dx.doi.org/10.6000/1927-5951.2013.03.02.2
Published: 30 April 2013


Abstract: On the basis of results in rat, L-arabinose decreased total cholesterol (TC), triglycerides (TG), fasting glucose, systolic blood pressure, increased high-density lipoprotein cholesterol (HDLC), and enhanced the glucose tolerance. The primary purposes of the present study was to determine the effects of consumption L-arabinose on metabolic syndrome in humans.All volunteers received L-Arabinose by dissolving it in water. The volunteers didn’t change the diet habits and lifestyles during the whole experiment. The trial lasted for 6 months, and experimental indicators were assayed every two months, which including weight, waist circumference, blood pressure, TG, TC, HDLC, low-density lipoprotein cholesterol (LDLC), fasting plasma glucose, erum uric acid, serum creatinine (Scr), bloodurea nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Our results showed that the L-arabinose decreased waist circumference, TC, fasting glucose, serum uric acid, ALT and slightly increased HDLCand slightly decreased diastolic blood pressure after 6 months. A tendency for decreased waist circumference, TC, fasting glucose, serum uric acid, ALT after 2, 4 and 6 months of treatment with L-arabinose was observed. In addition, L-arabinose decreased TC, LDLC and body weight. No effects on Scr, BUN, AST. In conclusions, L-arabinose would reduce most the metabolic syndrome risk factors(decreased circumference, TC, fasting glucose, and so on), and treat the metabolic syndrome as a whole.The present study would provides strong evidence that long-term received L-arabinose would be manage metabolic syndrome.

Keywords: L-arabinose, metabolic syndrome, triglycerides,ALT, waist circumference.
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