Journal of Research Updates in Polymer Science

Carboxylated Magnetite Composite Polymer Nanoparticles with Mosaic Structure for Biomedical Application
Pages 127-133
Kesavarao Sykam and Shailaja Donempudi


Published: 28 July 2015

Abstract: In this article, a microemulsion method for preparation of magnetite composite polymer nanoparticles of Fe3O4@poly(styrene-methacrylic acid) (MNP@PSMA) crosslinked with1,6-hexanediol diacrylate (HDD) insitu with carboxyl functionality on the surface has been reported. Structure and morphology of the nanoparticles was studied by Fourier Transform Infrared spctroscopy (FTIR), X ray Diffraction (XRD), Thermal Gravimetric Analyser (TGA), Vibrating Sample Magnetometer (VSM) and Transmission Electron Microscopy (TEM). VSM studies confirmed saturation magnetization of 20.0 emu/g in an external magnetic field. Nanoparticles formed were of 30 nm in diameter with narrow size distribution and mosaic structure providing a large surface area useful for application in bioseparation. Experimental results of covalent coupling of composite nanoparticles indicated maximum protein binding capacity of 350 mg bovine serum albumin (BSA) per gram.

Keywords: Microemulsion, magnetic nanoparticle supports, protein separation.
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