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Association between Obesity, Race and Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Pages 224-230
Xin He, Xiaoxiao Lu, Shuo Chen, Marc C. Hochberg and Mei-Ling Ting Lee
Published: 05 August 2014

Abstract: On the basis of longitudinal Kellgren-Lawrence (KL) grades of knee radiographsobtained from the Multicenter Osteoarthritis Study (MOST), we examine the association of obesity and race with severity of knee osteoarthritis (OA). We use the proportional odds model with mixed effects to conduct the analysis. Repeated KL grades were modeled as ordinal longitudinal measures, and a random effect term was included to adjust for the within-subject correlation among the KL grades over time. We found that African Americans and more obese participants in MOST have a greater risk of developing severe knee OA.

Keywords: Body mass index, Cumulative logits, Kellgren-Lawrence (KL) grade, Knee radiograph, Longitudinal ordinal data, Mixed effects model, Proportional odds model, Risk factors.
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