Specificities of Communication in Children with Intellectual Disorders  - Pages 602-609

Oksana V. Zashchirinskaia

DOI: https://doi.org/10.6000/2292-2598.2020.08.04.2

Published: 27 November 2020

Abstract: Objective: The purpose of this work is to study the characteristics of communication in children with intellectual disabilities.

Background: The study of the specificities of communication in children with intellectual disabilities has become more and more relevant in the past few years.

Method: The methodological basis of this study was the combination of various theoretical methods of cognition.

Results: In the process of writing this work, the author studied the techniques of verbal and non-verbal communication. The works of Russian and foreign authors, as well as methods of improving communication in children with intellectual disabilities, were considered. It was found that the impact of intellectual disabilities with mild mental retardation on the cognitive, behavioural and emotional-personal spheres of the communicative process naturally entails the emergence of serious difficulties in establishing contacts with people around, and therefore in the process of social adaptation of the child in general.

Conclusion: The practical significance of this work lies in the study of the characteristics of communication in children with intellectual disabilities, which will be useful for psychologists, teachers and medical workers. The study and research of this topic will provide further opportunities for the development of a program of psychological influence to optimise communication for children with intellectual disabilities and their adaptation in society.

Keywords: Intellectual impairment, mental retardation, social interaction, social adaptation, non-verbal communication, verbal communication.

Students’ Humanistic Position Formation in the Educational Process  - Pages 472-484

Svitlana O. Shara, Larisa I. Vorona, Iryna O. Kalinichenko, Lesia V. Lebedyk and Larisa M. Olifira

DOI: https://doi.org/10.6000/2292-2598.2020.08.03.25

Published: 14 September 2020

Abstract: Objective: The student's humanistic position is not only the result of the teacher's personal influence but also a controlled process. As a result of the implementation of this process, the student receives an understanding of what should relate to the humanistic process and the humanistic function of society.

Background: The basis for the formation of humanism for all participants in the students' educational process is determined either by the teacher's position or by the installation in the pedagogical process. So, any impact on the part of the teacher can be perceived as an exceptional factor of influencing the student's personality, which can be perceived as a compulsory education requirement.

Method: Assessment of pedagogical effectiveness was carried out by means of an expert survey. Diagnostic and processing of empirical data was carried out according to the methodology for assessing the importance of each individual requirement for the proposed educational materials.

Results: The study examines the components that form the student’s humanistic position on the basis of the traditional components of the formation of the pedagogical teaching strategy. The practical significance of the study is determined by the fact that it is possible to implement the concept of the formation of active skills in students during certain actions and the formation of other humanitarian positions.

Conclusion: The study shows that the level of formation of the students' humanistic position concerning all participants in the educational process depends on updating the educational process of training specialists based on the developed theoretical and methodological foundations.

Keywords: Humanism, position, training, students, university.

Spiritual Culture Formation of Young Teachers in the System of Higher Education: The Way for Social Maturity Development  - Pages 650-656

Zhannur Asetova, Saltanat Abildina, Albina Zh. Anesova, Zaure Kystaubayeva and Anar Ryskeldina

DOI: https://doi.org/10.6000/2292-2598.2020.08.04.7
Published: 27 November 2020

Abstract: The formation of spiritual culture should be based on the principles that guide every teacher in the implementation of their pedagogical skills in direct learning. The purpose of our study is to substantiate that young teachers' social maturity is characterized not only by the level of knowledge, development of their orientations but also by the degree of personal spiritual culture. We have applied the method of diagnosing a level of young teacher's social maturity development as a moderator in the search for spiritual values, but also a participant in the formation of personal spiritual culture directly at the student himself. Diagnostic sections have shown that the index of general social maturity of young teachers who shape the spiritual culture of students, is growing much faster compared to the young teachers who didn't show the activity of this kind. From the experimental data, it follows that young teachers' activity in creating a pedagogical environment of their school is an effective factor in the intensification of their social maturity formation. Investigating the problem of the formation of social maturity of the individual, a certain system of personal orientations develops, which serves as the basis of spiritual culture, which the student can choose. The authors show that such an opportunity can only be implemented with the teacher's integrated participation as a carrier of moral values. The study's novelty is determined by the fact that each of the participants in the educational process seeks to realize the share and type of moral views for the fulfillment of their personal interests. The study's practical significance is determined by the fact that spiritual culture can be based not only on its private but also on its public perception.

Keywords: Social relations assimilation, level of knowledge, spiritual culture, pedagogical environment.

Study of a Nano-Oleuropein’s Effect on the TCA Cycle`s Protein Expression in the Breast Cancer Cell Line Using Proteomics - Pages 47-52

Kamrani Solmaz, Khatere Tooba and Mohammad Zaefizadeh

DOI: https://doi.org/10.6000/2292-2598.2019.07.02.3

Published: 11 May 2019

Abstract: Breast cancer is the most common cancer and a common cause of death, which occurs due to cancer among women in the world. Cancer cells need a lot of energy to their uncontrolled growth, so it seems that the expression of the enzyme in the Krebs cycle is changing. There are some reports about mutations and altered expression of succinate dehydrogenase, fumarate Hydratase, and isocitrate dehydrogenase in human cancers. This research aimed to investigate the role of magnetite nanoparticle Oleuropein on the Krebs cycle proteins expression on the breast cancer cell line. Oleuropein is one of the polyphenolic components in olive trees and has some benefits in some diseases, including cancer. In addition to testing the viability test MTT (3- 4,5 Dimethylthiazol-2-yl -2,5-diphenyltetrazolium bromide) assay, in three levels of Oleuropein 0ppm, 300ppm, 600ppm proteomics analysis was also performed in cell line MCF7 in this study. The results of differential protein spots identification into two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MS-MALDI-TOF-TOF), showed that fumarylacetoacetate hydrolase, succinate-coenzyme A ligase and isocitrate dehydrogenase1 are differential proteins upregulated after treated with 300ppm and 600ppm of oleuropein. It seems that Nano Oleuropein is a booster of Krebs cycle with upregulation of Fumarylacetoacetase, succinate-CoA ligase, and isocitrate dehydrogenase1. Uncoordinated Overexpression of some Krebs cycle protein can be one of the inhibition mechanisms on the breast cancer cell line under Oleuropein treatment.

Keywords: Breast cancer, Oleuropein, Krebs cycle, Proteomics.

Download