jnt
Abstract : Platelets Mitochondrial Function Depends on Coenzyme Q10 Concentration in Human Young, Not in Elderly Subjects
|
|
|
Abstract: Ageing is characterized by a progressive decline in the physiological functions of various organs. Mitochondrial alterations occurring in senescence. Antioxidants, including coenzyme Q10 concentration, fall with ageing and contribute to enhanced oxidative stress age-related diseases. The impairment of platelet mitochondrial function occurs in a broad spectrum of diseases. The aim of this study was to evaluate mitochondrial function in platelets in elderly and young human controls and correlate it with a concentration of coenzyme Q10. Platelets mitochondrial function was determined by the use of High-Resolution Respirometry method. We did not find significantly decreased platelet mitochondrial function in elderly subjects. Dependence of platelets mitochondrial respiratory chain function and ATP production at Complex I on a concentration of coenzyme Q10 in platelets and whole blood in young not in elderly human volunteers was documented. This dependence was not found for Complex II in any group. Platelet mitochondrial coenzyme Q10 concentration was insufficient for improving platelet mitochondrial function in elderly human subjects. Recommending supplementation with coenzyme Q10 in elderly and aged humans is waranted. High-Resolution Respirometry method offers a perspective to diagnose mitochondrial energy metabolism which might be useful for further studies in patients with mitochondrial disorders. Our results could contribute to the explanation of platelets mitochondrial function in elderly and aged human subjects. Keywords: Platelets, mitochondria, High-Resolution Respirometry, coenzyme Q10, age.
|
Abstract : Effect of Combination of L-Arginine and L-Carnitine on Serum AGEs Level, Kidney and Endothelial Function in Patients with Chronic Heart Failure
|
|
|
Abstract: The aim of the study to evaluate the effect of combination of L-Arginine with L-Carnitine on GFR, serum AGEs level and endothelial function in chronic heart failure (HF) patients with preserved ejection fraction (HFpEF). Materials and Methods: 35 patients with mean age 60,1 [56,7; 77,3] years with an established diagnosis of HFpEF were enrolled. The patients were randomly and blindly divided into 2 groups: first (1st) group pts were treated with a combination of L-Carnitine and L-Arginine in addition to standard treatment; 2nd group pts – with L-Arginine in addition to conventional treatment. Standard laboratory blood tests, lipid profile, glucose, renal and liver function tests, serum advanced glycation end-product (AGEs) level, echocardiographic examination, flow-mediated dilatation (FMD%) were performed for all patients baseline and after 10 days of treatment. The glomerular filtration rate (GFR) was estimated using the CKD-EPI formula. Results: Median level of AGEs was 1.72 [1.34; 1.93] mg/ml. The level of AGEs was correlated with age (R = 0.71, p<0.05), disease duration (R = 0.69, p<0.05). After 10 days of treatment with a combination of L-Carnitine with L-Arginine mean AGEs was decreased by 13.1% in comparison with L-Arginine treatment group (p=0.0003). After the treatment in 1st group mean AGEs was significantly lower in comparison with the 2nd group (p=0.004). Baseline median level of GFR was 81.2 [72,1; 86,2] ml/min and correlated with disease duration (R = 0.71, p<0.05), AGEs level (R = -0.73, p<0.05). The inclusion combination of L-arginine aspartate with L-Carnitine contributed to the significant increase of GFR level (p=0.003). The median FMD% level was 6.2 [4.4; 7.9] % and correlated with age (R=-0.61, p < 0.05), GFR (R=0.54, p < 0.05). After the 10 days it had been established significant increasing of FMD% level on 47.9 % in 1st group (p=0.0005), and on 29.3 % in 2nd group (p=0.003). Endothelial function normalizing was achieved in 10 (66 %) pts of 1st group and in 9 (45%) pts of 2nd group (p=0.002). Conclusion: The combination of L-Carnitine, and L-Arginine improves kidney, endothelial function and contributes to decreasing of AGEs level in pts with HFpEF. Keywords: L-arginine, L-carnitine, kidney function, endothelial function, chronic heart failure.
|
Abstract : Beneficial Effects of Pomegranate Fruit Consumption in Cardiovascular Diseases Prevention
|
|
|
Abstract: Oxidative stress, dyslipidemia, hypercoagulability, endothelial dysfunction and inflammation are key elements in the development of atherosclerosis. Oxidative stress has been implicated as well in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of cardiovascular diseases. In addition to the formation of atherosclerosis, oxidative stress acute thrombotic events, including dyslipidemia, the oxidation of low-density lipoproteins (LDLs) and plaque rupture leading to atherothrombosis and myocardial infarction. In the last decades, multiple experimental studies and clinical trials have demonstrated that diet plays a central role in the prevention of atherosclerosis. Pomegranate (Punica granatum L.) is one of nature’s most concentrated sources of antioxidants. It contains some very potent antioxidants (i.e. tannins, anthocyanins and flavonoids), which provide a wide spectrum of action against free radicals and are considered to be potent anti-atherogenic products. These properties make pomegranate a healthy fruit with a high potential in preventing cardiovascular diseases. In this review, we give an overview on the newest insights in the role of pomegranate in therapy of vascular diseases. Keywords: Pomegranate, atherosclerosis, antioxidants, cardiovascular diseases, oxidation. |
Abstract : Psychology Aspects of Eating Behaviors is a Nutrition and Health Problem
|
|
|
Abstract: In recent years, overweight and obesity have reached the status of a global pandemic and are particularly prevalent in the world. Overweight and obesity identified as risk factors for several health problems, including type 2 diabetes, hypertension, coronary heart disease and stroke. In recognition of the fact that reducing the burden of obesity and overweight has the potential to decrease mortality and disease worldwide, the World Health Organisation established that promoting healthy diets and physical activity is now a public health priority. Keywords: Psychology, Eating, Behaviors, Nutrition, Health, problem. |
Abstract : Nutritional Behaviour is a Social Problem in the Modern Lifestyle
|
|
|
Abstract: The purpose of this study is to observe, analyze, compare and educate young people's dietary behaviour. It was noticed that the consumption of fruits and vegetables is low, restricted in many cases to one or two servings per day. This result led to the conclusion that healthy food does not play an important role in young people's eating habits. Given this situation, in a few years, childhood obesity rates could rise alarmingly. Keywords: Food, fruits and vegetables, young population, nutrition education, healthy habits. |